CD 1530

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Cat.No. 2554 - CD 1530 | C27H26O3 | CAS No. 107430-66-0
Description: Potent and selective RARγ agonist
Chemical Name: 4-(6-Hydroxy-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Potent and selective RARγ receptor agonist (Ki values are 150, 1500 and 2750 nM for RARγ, RARβ and RARα receptors respectively). Activates transcriptional activity (AC50 = 1.8 nM).

Technical Data

M. Wt 398.49
Formula C27H26O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 107430-66-0
PubChem ID 24868309
InChI Key YSGDXEKQTNMRQN-UHFFFAOYSA-N
Smiles OC(=O)C1=CC=C(C=C1)C1=CC=C2C=C(C(O)=CC2=C1)C12CC3CC(CC(C3)C1)C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 398.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.55 mL 25.09 mL
5 mM 0.5 mL 2.51 mL 5.02 mL
10 mM 0.25 mL 1.25 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Thacher et al (2000) Therapeutic applications for ligands of retinoid receptors. Curr.Pharmaceut.Des. 6 25 PMID:


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Keywords: CD 1530, supplier, Potent, selective, RARγ, RARgamma, agonists, RAMBA, Retinoic, Acid, Receptors, CD1530, Retinoic, Acid, Receptors, Retinoic, Acid, Receptors, Tocris Bioscience

2 Citations for CD 1530

Citations are publications that use Tocris products. Selected citations for CD 1530 include:

Garnaas et al (2012) Rargb regulates organ laterality in a zebrafish model of right atrial isomerism. Dev Biol 372 178 PMID: 22982668

Duprey-Díaz et al (2016) Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System afterOptic Nerve Injury PLoS One 11 e0162626 PMID: 27611191


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