CCT 241533 dihydrochloride

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Potent Chk2 inhibitor
Chemical Name: (3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihydrochloride
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for CCT 241533 dihydrochloride

CCT 241533 dihydrochloride is a potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.

Licensing Information

Sold under license from Cancer Research Technology Ltd (Ximbio).

External Portal Information for CCT 241533 dihydrochloride is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CCT 241533 is reviewed on the chemical probes website.

Compound Libraries for CCT 241533 dihydrochloride

CCT 241533 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for CCT 241533 dihydrochloride

M. Wt 515.41
Formula C23H27FN4O4.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1962925-28-5
PubChem ID 49867844
Smiles FC1=CC(C3=NC2=CC(OC)=C(OC)C=C2C(N[C@H]4[C@H]([C@](C)(O)C)CNC4)=N3)=C(O)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CCT 241533 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 5.15 10 with gentle warming
DMSO 51.54 100

Preparing Stock Solutions for CCT 241533 dihydrochloride

The following data is based on the product molecular weight 515.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.7 mL 19.4 mL
5 mM 0.39 mL 1.94 mL 3.88 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for CCT 241533 dihydrochloride

References for CCT 241533 dihydrochloride

References are publications that support the biological activity of the product.

Caldwell et al (2011) Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J.Med.Chem. 54 580 PMID: 21186793

If you know of a relevant reference for CCT 241533 dihydrochloride, please let us know.

View Related Products by Product Action

View all Checkpoint Kinase Inhibitors

Keywords: CCT 241533 dihydrochloride, CCT 241533 dihydrochloride supplier, checkpoint, kinase, 2, CHK, inhibitors, inhibits, radioprotectant, potent, selective, Checkpoint, Kinases, Control, 4968, Tocris Bioscience

Citations for CCT 241533 dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for CCT 241533 dihydrochloride. Do you know of a great paper that uses CCT 241533 dihydrochloride from Tocris? Please let us know.

Reviews for CCT 241533 dihydrochloride

There are currently no reviews for this product. Be the first to review CCT 241533 dihydrochloride and earn rewards!

Have you used CCT 241533 dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.