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View all Angiotensin AT<sub>1</sub> Receptors products.Candesartan is an angiotensin II receptor 1 (AT1) antagonist (IC50 values are 1.12 and 2.86 nM in bovine adrenal cortex and rabbit aorta, respectively). Exhibits antihypertensive effects in animal models. Also available as a prodrug, candesartan cilexetil (Cat. No. 4792).
Candesartan is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
M. Wt | 440.45 |
Formula | C24H20N6O3 |
Storage | Store at RT |
Purity | ≥98% (HPLC) |
CAS Number | 139481-59-7 |
PubChem ID | 2541 |
InChI Key | HTQMVQVXFRQIKW-UHFFFAOYSA-N |
Smiles | CCOC1=NC(C=CC=C5C(O)=O)=C5N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Shibouta et al (1993) Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonylox J.Pharmacol.Exp.Ther. 266 114 PMID: 8331552
Keywords: Candesartan, Candesartan supplier, Angiotensin, II, receptors, AT1, antagonists, CV11974, CV, 11974, Receptors, 4791, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Candesartan include:
Gemma et al (2021) Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19. Clin Sci (Lond) 135 465-481 PMID: 33479758
Milan et al (2021) Transcriptomic Analysis of Mouse Brain After Traumatic Brain Injury Reveals That the Angiotensin Receptor Blocker Candesartan Acts Through Novel Pathways. Front Neurosci 15 636259 PMID: 33828448
Ana et al (2022) Angiotensin Type-1 Receptor Inhibition Reduces NLRP3 Inflammasome Upregulation Induced by Aging and Neurodegeneration in the Substantia Nigra of Male Rodents and Primary Mesencephalic Cultures. Antioxidants (Basel) 11 PMID: 35204211
Rita et al (2022) Angiotensin type-1 receptor and ACE2 autoantibodies in Parkinson´s disease. NPJ Parkinsons Dis 8 76 PMID: 35701430
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