Home / Pharmacology / GPCRs / 7-TM Receptors / Peptide Receptors / Angiotensin Receptors / Angiotensin AT1 Receptors / Angiotensin AT1 Receptor Antagonists / Candesartan

Candesartan

Cat. No. 4791 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: AT1 antagonist
Alternative Names: CV 11974
Chemical Name: 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Candesartan

Candesartan is an angiotensin II receptor 1 (AT1) antagonist (IC50 values are 1.12 and 2.86 nM in bovine adrenal cortex and rabbit aorta, respectively). Exhibits antihypertensive effects in animal models. Also available as a prodrug, candesartan cilexetil (Cat. No. 4792).

Compound Libraries for Candesartan

Candesartan is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Candesartan

M. Wt 440.45
Formula C24H20N6O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 139481-59-7
PubChem ID 2541
InChI Key HTQMVQVXFRQIKW-UHFFFAOYSA-N
Smiles CCOC1=NC(C=CC=C5C(O)=O)=C5N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Candesartan

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.45 100
ethanol 0.44 10 with gentle warming

Preparing Stock Solutions for Candesartan

The following data is based on the product molecular weight 440.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.14 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for Candesartan

References are publications that support the biological activity of the product.

Shibouta et al (1993) Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonylox J.Pharmacol.Exp.Ther. 266 114 PMID: 8331552

If you know of a relevant reference for Candesartan, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Angiotensin AT1 Receptor Antagonists

Keywords: Candesartan, Candesartan supplier, Angiotensin, II, receptors, AT1, antagonists, CV11974, CV, 11974, Receptors, 4791, Tocris Bioscience

Citations for Candesartan

Citations are publications that use Tocris products.

Currently there are no citations for Candesartan. Do you know of a great paper that uses Candesartan from Tocris? Please let us know.

Reviews for Candesartan

There are currently no reviews for this product. Be the first to review Candesartan and earn rewards!

Have you used Candesartan?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors Product Listing

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Cardiovascular Poster

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.