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Description: AT1 antagonist
Alternative Names: CV 11974
Chemical Name: 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid
Purity: ≥98% (HPLC)
Citations (4)

Biological Activity for Candesartan

Candesartan is an angiotensin II receptor 1 (AT1) antagonist (IC50 values are 1.12 and 2.86 nM in bovine adrenal cortex and rabbit aorta, respectively). Exhibits antihypertensive effects in animal models. Also available as a prodrug, candesartan cilexetil (Cat. No. 4792).

Compound Libraries for Candesartan

Candesartan is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Candesartan

M. Wt 440.45
Formula C24H20N6O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 139481-59-7
PubChem ID 2541
Smiles CCOC1=NC(C=CC=C5C(O)=O)=C5N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Candesartan

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.45 100
ethanol 0.44 10 with gentle warming

Preparing Stock Solutions for Candesartan

The following data is based on the product molecular weight 440.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.14 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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References for Candesartan

References are publications that support the biological activity of the product.

Shibouta et al (1993) Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonylox J.Pharmacol.Exp.Ther. 266 114 PMID: 8331552

If you know of a relevant reference for Candesartan, please let us know.

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Keywords: Candesartan, Candesartan supplier, Angiotensin, II, receptors, AT1, antagonists, CV11974, CV, 11974, Receptors, 4791, Tocris Bioscience

4 Citations for Candesartan

Citations are publications that use Tocris products. Selected citations for Candesartan include:

Gemma et al (2021) Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19. Clin Sci (Lond) 135 465-481 PMID: 33479758

Milan et al (2021) Transcriptomic Analysis of Mouse Brain After Traumatic Brain Injury Reveals That the Angiotensin Receptor Blocker Candesartan Acts Through Novel Pathways. Front Neurosci 15 636259 PMID: 33828448

Ana et al (2022) Angiotensin Type-1 Receptor Inhibition Reduces NLRP3 Inflammasome Upregulation Induced by Aging and Neurodegeneration in the Substantia Nigra of Male Rodents and Primary Mesencephalic Cultures. Antioxidants (Basel) 11 PMID: 35204211

Rita et al (2022) Angiotensin type-1 receptor and ACE2 autoantibodies in Parkinson´s disease. NPJ Parkinsons Dis 8 76 PMID: 35701430

Do you know of a great paper that uses Candesartan from Tocris? Please let us know.

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