Candesartan

Pricing Availability Delivery Time Qty
Cat.No. 4791 - Candesartan | C24H20N6O3 | CAS No. 139481-59-7
Description: AT1 receptor antagonist
Alternative Names: CV 11974
Chemical Name: 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Angiotensin II receptor 1 (AT1) antagonist (IC50 values are 1.12 and 2.86 nM in bovine adrenal cortex and rabbit aorta, respectively). Exhibits antihypertensive effects in animal models. Also available as a prodrug, candesartan cilexetil (Cat. No. 4792).

Compound Libraries

Candesartan is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 440.45
Formula C24H20N6O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 139481-59-7
PubChem ID 2541
InChI Key HTQMVQVXFRQIKW-UHFFFAOYSA-N
Smiles CCOC1=NC(C=CC=C5C(O)=O)=C5N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.45 100
ethanol 0.44 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 440.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.14 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Shibouta et al (1993) Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonylox J.Pharmacol.Exp.Ther. 266 114 PMID: 8331552


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Keywords: Candesartan, supplier, Angiotensin, II, receptors, AT1, antagonists, CV11974, CV, 11974, Angiotensin, AT1, Receptors, Tocris Bioscience

Citations for Candesartan

Citations are publications that use Tocris products.

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Literature in this Area

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Pathways for Candesartan

Protocols

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