Candesartan cilexetil
Biological Activity
Prodrug of the angiotensin II receptor 1 (AT1) antagonist candesartan (Cat. No. 4791), which exhibits antihypertensive effects in animal models.
Technical Data
| M. Wt | 610.66 |
| Formula | C33H34N6O6 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 145040-37-5 |
| PubChem ID | 2540 |
| InChI Key | GHOSNRCGJFBJIB-UHFFFAOYSA-N |
| Smiles | CCOC1=NC(C=CC=C5C(OC(C)OC(OC6CCCCC6)=O)=O)=C5N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 61.07 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 610.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.64 mL | 8.19 mL | 16.38 mL |
| 5 mM | 0.33 mL | 1.64 mL | 3.28 mL |
| 10 mM | 0.16 mL | 0.82 mL | 1.64 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Shibouta et al (1993) Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonylo J.Pharmacol.Exp.Ther. 266 114 PMID: 8331552
Nishikawa et al (1997) Candesartan cilexetil: a review of its preclinical pharmacology. J.Hum.Hypertens. Suppl2 9 PMID: 9330999
If you know of a relevant reference for Candesartan cilexetil, please let us know.
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Citations for Candesartan cilexetil
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