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Biological Activity for Candesartan cilexetil
Candesartan cilexetil is a prodrug of the angiotensin II receptor 1 (AT1) antagonist candesartan (Cat. No. 4791), which exhibits antihypertensive effects in animal models.
Technical Data for Candesartan cilexetil
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Candesartan cilexetil
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Candesartan cilexetil
The following data is based on the product molecular weight 610.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.64 mL||8.19 mL||16.38 mL|
|5 mM||0.33 mL||1.64 mL||3.28 mL|
|10 mM||0.16 mL||0.82 mL||1.64 mL|
|50 mM||0.03 mL||0.16 mL||0.33 mL|
Product Datasheets for Candesartan cilexetil
References for Candesartan cilexetil
References are publications that support the biological activity of the product.
Shibouta et al (1993) Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonylo J.Pharmacol.Exp.Ther. 266 114 PMID: 8331552
Nishikawa et al (1997) Candesartan cilexetil: a review of its preclinical pharmacology. J.Hum.Hypertens. Suppl2 9 PMID: 9330999
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Keywords: Candesartan cilexetil, Candesartan cilexetil supplier, TCV116, angiotensin, II, anagonists, AT1, receptors, candesartan, cilexetil, prodrug, TCV, 116, Angiotensin, Receptors, 4792, Tocris Bioscience
Citations for Candesartan cilexetil
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Literature in this Area
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