Candesartan cilexetil

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Cat.No. 4792 - Candesartan cilexetil | C33H34N6O6 | CAS No. 145040-37-5
Description: Prodrug of candesartan (Cat. No. 4791), an AT1 receptor antagonist
Alternative Names: TCV 116
Chemical Name: 2-Ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

Prodrug of the angiotensin II receptor 1 (AT1) antagonist candesartan (Cat. No. 4791), which exhibits antihypertensive effects in animal models.

Technical Data

M. Wt 610.66
Formula C33H34N6O6
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 145040-37-5
PubChem ID 2540
InChI Key GHOSNRCGJFBJIB-UHFFFAOYSA-N
Smiles CCOC1=NC(C=CC=C5C(OC(C)OC(OC6CCCCC6)=O)=O)=C5N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 61.07 100

Preparing Stock Solutions

The following data is based on the product molecular weight 610.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.19 mL 16.38 mL
5 mM 0.33 mL 1.64 mL 3.28 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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References

References are publications that support the biological activity of the product.

Shibouta et al (1993) Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonylo J.Pharmacol.Exp.Ther. 266 114 PMID: 8331552

Nishikawa et al (1997) Candesartan cilexetil: a review of its preclinical pharmacology. J.Hum.Hypertens. Suppl2 9 PMID: 9330999


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Citations for Candesartan cilexetil

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Literature in this Area

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