Calpeptin

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Cat.No. 0448 - Calpeptin | C20H30N2O4 | CAS No. 117591-20-5
Description: Calpain and cathepsin L inhibitor
Chemical Name: N-Benzyloxycarbonyl-L-leucylnorleucinal
Datasheet
Citations (6)

Biological Activity

Potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases.

Compound Libraries

Calpeptin is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 362.47
Formula C20H30N2O4
Storage Desiccate at +4°C
CAS Number 117591-20-5
PubChem ID 73364
InChI Key PGGUOGKHUUUWAF-ROUUACIJSA-N
Smiles O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@H](C([H])=O)CCCC)=O)CC(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 362.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.79 mL 27.59 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Mehdi (1991) Cell-penetrating inhibitors of calpain. TiBS 16 150 PMID: 1877091

Sasaki et al (1990) Inhibitory effect of di-and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 3 195 PMID: 2079636

Schoenwaelder and Burridge (1999) Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the small GTPase Rho. J.Biol.Chem. 274 14359 PMID: 10318859

Tsujinaka et al (1988) Synthesis of a new cell penetrating calpain inhibitor (calpeptin). Biochem.Biophys.Res.Commun. 153 1201 PMID: 2839170


If you know of a relevant reference for Calpeptin, please let us know.

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View all Calcium-Sensitive Protease Modulator Inhibitors

Keywords: Calpain cathepsin L inhibitors inhibits Proteinases Proteases Ca2+Sensitive Protease modulators Calcium-Sensitive Ca2+ Signaling Signalling Calcium-Sensitive Protease Modulators

6 Citations for Calpeptin

Citations are publications that use Tocris products. Selected citations for Calpeptin include:

Rivera-Pagán et al (2015) Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia. PLoS One 10 e0125195 PMID: 25886567

Machado et al (2015) Involvement of calpains in adult neurogenesis: implications for stroke. J Biol Chem 9 22 PMID: 25698931

Wang et al (2015) MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons. J Pharmacol Exp Ther 290 168 PMID: 25416777

Redpath et al (2014) Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair. Mol Biol Cell 25 3037 PMID: 25143396

Chen et al (2013) Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: functional significance and signaling mechanisms. Pflugers Arch 347 765 PMID: 24030012

Amadoro et al (2006) NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation. Proc Natl Acad Sci U S A 103 2892 PMID: 16477009


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