BW 373U86

Discontinued Product

BW 373U86 (Cat. No. 1663) has been withdrawn from sale for commercial reasons.
Description: Potent, selective non-peptide δ agonist
Chemical Name: 4-[(αR*)-α-((2S*,5R*)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl]-N,N-diethylbenzamide
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for BW 373U86

BW 373U86 is a potent, selective non-peptide δ-opioid receptor agonist. Ki values are 1.8, 15 and 34 nM for δ, μ and κ receptors respectively. Centrally active following systemic administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for BW 373U86

M. Wt 435.61
Formula C27H37N3O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 155836-50-3
PubChem ID 119029
Smiles O=C(N(CC)CC)C1=CC=C([C@@]([H])(N3C[C@@H](C)N(CC=C)C[C@@H]3C)C2=CC(O)=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for BW 373U86

Certificate of Analysis / Product Datasheet
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References for BW 373U86

References are publications that support the biological activity of the product.

Broom et al (2002) Comparison of receptor mechanisms and efficacy requirements for δ-agonist-induced convulsive activity and antinociception in mice. J.Pharmacol.Exp.Ther. 303 723 PMID: 12388657

Chang et al (1993) A novel, potent and selective nonpeptidic delta opioid receptor agonist BW373U86. J.Pharmacol.Exp.Ther. 267 852 PMID: 8246159

Dykstra et al (1993) A novel delta opioid agonist, BW373U86, in squirrel monkeys responding under a schedule of shock titration. J.Pharmacol.Exp.Ther. 267 875 PMID: 8246162

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Keywords: BW 373U86, BW 373U86 supplier, Potent, selective, non-peptide, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, BW373U86, GlaxoSmithKline, GSK, Delta, Opioid, 1663, Tocris Bioscience

1 Citation for BW 373U86

Citations are publications that use Tocris products. Selected citations for BW 373U86 include:

Donner et al (2013) Obesity improves myocardial ischaemic tolerance and RISK signalling in Ins-insensitive rats. J Allergy Clin Immunol 6 457 PMID: 23161371

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.