BW 373U86

Pricing Availability Delivery Time Qty
Cat.No. 1663 - BW 373U86 | C27H37N3O2 | CAS No. 155836-50-3
Description: Potent, selective non-peptide δ agonist
Chemical Name: 4-[(αR*)-α-((2S*,5R*)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl]-N,N-diethylbenzamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent, selective non-peptide δ-opioid receptor agonist. Ki values are 1.8, 15 and 34 nM for δ, μ and κ receptors respectively. Centrally active following systemic administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M. Wt 435.61
Formula C27H37N3O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 155836-50-3
PubChem ID 119029
InChI Key LBLDMHBSVIVJPM-YZIHRLCOSA-N
Smiles O=C(N(CC)CC)C1=CC=C([C@@]([H])(N3C[C@@H](C)N(CC=C)C[C@@H]3C)C2=CC(O)=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 43.56 100
DMSO 10.89 25
ethanol 43.56 100

Preparing Stock Solutions

The following data is based on the product molecular weight 435.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.48 mL 22.96 mL
5 mM 0.46 mL 2.3 mL 4.59 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Broom et al (2002) Comparison of receptor mechanisms and efficacy requirements for δ-agonist-induced convulsive activity and antinociception in mice. J.Pharmacol.Exp.Ther. 303 723 PMID: 12388657

Chang et al (1993) A novel, potent and selective nonpeptidic delta opioid receptor agonist BW373U86. J.Pharmacol.Exp.Ther. 267 852 PMID: 8246159

Dykstra et al (1993) A novel delta opioid agonist, BW373U86, in squirrel monkeys responding under a schedule of shock titration. J.Pharmacol.Exp.Ther. 267 875 PMID: 8246162


If you know of a relevant reference for BW 373U86, please let us know.

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View all δ Opioid Receptor Agonists

Keywords: Potent selective non-peptide δ-opioid delta-opioid agonists DOP Receptors OP1 BW373U86 GlaxoSmithKline GSK Delta Opioid Receptors

1 Citation for BW 373U86

Citations are publications that use Tocris products. Selected citations for BW 373U86 include:

Donner et al (2013) Obesity improves myocardial ischaemic tolerance and RISK signalling in insulin-insensitive rats. J Allergy Clin Immunol 6 457 PMID: 23161371


Do you know of a great paper that uses BW 373U86 from Tocris? If so please let us know.

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