BVT 948

Pricing Availability Delivery Time Qty
Cat.No. 2176 - BVT 948 | C14H11NO3 | CAS No. 39674-97-0
Description: Non-competitive protein tyrosine phosphatase inhibitor; enhances insulin signaling
Chemical Name: 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC50 <10 μM).

Compound Libraries

BVT 948 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 241.25
Formula C14H11NO3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 39674-97-0
PubChem ID 6604934
InChI Key LLPBUXODFQZPFH-UHFFFAOYSA-N
Smiles CC1(C)C(=O)N=C2C1=C(O)C(=O)C1=CC=CC=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.06 50
ethanol 12.06 50

Preparing Stock Solutions

The following data is based on the product molecular weight 241.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.15 mL 20.73 mL 41.45 mL
5 mM 0.83 mL 4.15 mL 8.29 mL
10 mM 0.41 mL 2.07 mL 4.15 mL
50 mM 0.08 mL 0.41 mL 0.83 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Liljebris et al (2004) Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione. J.Pharmacol.Exp.Ther. 309 711 PMID: 14747616


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View all Protein Tyrosine Phosphatases Inhibitors

Keywords: Non-competitive protein tyrosine phosphatase inhibitors inhibits enhances insulin signaling PTP Shp1 Shp2 Protein Tyrosine Phosphatases BVT948 Protein Tyrosine Phosphatases

1 Citation for BVT 948

Citations are publications that use Tocris products. Selected citations for BVT 948 include:

Hwang et al (2013) Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9. Am J Physiol Cell Physiol 46 533 PMID: 24152909


Do you know of a great paper that uses BVT 948 from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for BVT 948

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