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Biological Activity for BVT 948
BVT 948 is a non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC50 <10 μM).
Compound Libraries for BVT 948
Technical Data for BVT 948
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BVT 948
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BVT 948
The following data is based on the product molecular weight 241.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||8.29 mL||41.45 mL||82.9 mL|
|2.5 mM||1.66 mL||8.29 mL||16.58 mL|
|5 mM||0.83 mL||4.15 mL||8.29 mL|
|25 mM||0.17 mL||0.83 mL||1.66 mL|
References for BVT 948
References are publications that support the biological activity of the product.
Liljebris et al (2004) Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione. J.Pharmacol.Exp.Ther. 309 711 PMID: 14747616
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Keywords: BVT 948, BVT 948 supplier, Non-competitive, protein, tyrosine, phosphatase, inhibitors, inhibits, enhances, insulin, signaling, PTP, Shp1, Shp2, Protein, Tyrosine, Phosphatases, BVT948, 2176, Tocris Bioscience
2 Citations for BVT 948
Citations are publications that use Tocris products. Selected citations for BVT 948 include:
Hwang et al (2013) Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9. Am J Physiol Cell Physiol 46 533 PMID: 24152909
Chen et al (2014) BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci 39 1439 PMID: 24611998
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Literature in this Area
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