BVT 948

Pricing Availability   Qty
Cat.No. 2176 - BVT 948 | C14H11NO3 | CAS No. 39674-97-0
Description: Non-competitive protein tyrosine phosphatase inhibitor
Chemical Name: 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)

Biological Activity

Non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC50 <10 μM).

Compound Libraries

BVT 948 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 241.25
Formula C14H11NO3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 39674-97-0
PubChem ID 6604934
InChI Key LLPBUXODFQZPFH-UHFFFAOYSA-N
Smiles CC1(C)C(=O)N=C2C1=C(O)C(=O)C1=CC=CC=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 12.06 50
DMSO 12.06 50

Preparing Stock Solutions

The following data is based on the product molecular weight 241.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.29 mL 41.45 mL 82.9 mL
2.5 mM 1.66 mL 8.29 mL 16.58 mL
5 mM 0.83 mL 4.15 mL 8.29 mL
25 mM 0.17 mL 0.83 mL 1.66 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Liljebris et al (2004) Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione. J.Pharmacol.Exp.Ther. 309 711 PMID: 14747616


If you know of a relevant reference for BVT 948, please let us know.

View Related Products by Product Action

View all Protein Tyrosine Phosphatases Inhibitors

Keywords: BVT 948, BVT 948 supplier, Non-competitive, protein, tyrosine, phosphatase, inhibitors, inhibits, enhances, insulin, signaling, PTP, Shp1, Shp2, Protein, Tyrosine, Phosphatases, BVT948, 2176, Tocris Bioscience

2 Citations for BVT 948

Citations are publications that use Tocris products. Selected citations for BVT 948 include:

Chen et al (2014) BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci 39 1439 PMID: 24611998

Hwang et al (2013) Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9. Am J Physiol Cell Physiol 46 533 PMID: 24152909


Do you know of a great paper that uses BVT 948 from Tocris? Please let us know.

Reviews for BVT 948

There are currently no reviews for this product. Be the first to review BVT 948 and earn rewards!

Have you used BVT 948?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis