BVT 948

Pricing Availability   Qty
Description: Non-competitive protein tyrosine phosphatase inhibitor
Chemical Name: 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity for BVT 948

BVT 948 is a non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC50 <10 μM).

Compound Libraries for BVT 948

BVT 948 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for BVT 948

M. Wt 241.25
Formula C14H11NO3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 39674-97-0
PubChem ID 6604934
Smiles CC1(C)C(=O)N=C2C1=C(O)C(=O)C1=CC=CC=C21

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BVT 948

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 12.06 50
DMSO 12.06 50

Preparing Stock Solutions for BVT 948

The following data is based on the product molecular weight 241.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.29 mL 41.45 mL 82.9 mL
2.5 mM 1.66 mL 8.29 mL 16.58 mL
5 mM 0.83 mL 4.15 mL 8.29 mL
25 mM 0.17 mL 0.83 mL 1.66 mL

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Product Datasheets for BVT 948

Certificate of Analysis / Product Datasheet
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References for BVT 948

References are publications that support the biological activity of the product.

Liljebris et al (2004) Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione. J.Pharmacol.Exp.Ther. 309 711 PMID: 14747616

If you know of a relevant reference for BVT 948, please let us know.

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View all Protein Tyrosine Phosphatases Inhibitors

Keywords: BVT 948, BVT 948 supplier, Non-competitive, protein, tyrosine, phosphatase, inhibitors, inhibits, enhances, insulin, signaling, PTP, Shp1, Shp2, Protein, Tyrosine, Phosphatases, BVT948, 2176, Tocris Bioscience

2 Citations for BVT 948

Citations are publications that use Tocris products. Selected citations for BVT 948 include:

Chen et al (2014) BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci 39 1439 PMID: 24611998

Hwang et al (2013) Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9. Am J Physiol Cell Physiol 46 533 PMID: 24152909

Do you know of a great paper that uses BVT 948 from Tocris? Please let us know.

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