BTS 54-505 hydrochloride

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Cat.No. 2322 - BTS 54-505 hydrochloride | C15H22NCl.HCl | CAS No. 84484-78-6
Description: Potent 5-HT and NA reuptake inhibitor (SNRI); active metabolite of sibutramine (Cat. No. 2290)
Chemical Name: 1-(4-Chlorophenyl)-α-(2-methylpropyl)cyclobutanemethanamine hydrochloride
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity

Potently active primary amine metabolite of sibutramine (Cat. No. 2290), exhibits a similar pharmacological profile to the parent compound. Inhibits serotonin and noradrenalin reuptake more potently than sibutramine in vitro. Reduces food intake in rodents following i.c.v. administration and increases energy expenditure via thermogenesis in vivo.

Technical Data

M. Wt 288.26
Formula C15H22NCl.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 84484-78-6
PubChem ID 134771
Smiles Cl.CC(C)CC(N)C1(CCC1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 14.41 50
DMSO 28.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 288.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.47 mL 17.35 mL 34.69 mL
5 mM 0.69 mL 3.47 mL 6.94 mL
10 mM 0.35 mL 1.73 mL 3.47 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

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References are publications that support the biological activity of the product.

Luscombe et al (1989) The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutr. hydrochloride. Neuropharmacology 28 129 PMID: 2541365

Gundlah et al (1997) In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutr. is a reuptake inhibitor. J.Pharmacol.Exp.Ther. 283 581 PMID: 9353373

Liu et al (2002) Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major pharmacologically active metabolite of the novel anti-obesity drug, sibutr. Int.J.Obes.Relat.Metab.Disord. 26 1245 PMID: 12187403

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