Sibutramine hydrochloride

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Cat.No. 2290 - Sibutramine hydrochloride | C17H26NCl.HCl | CAS No. 84485-00-7
Description: 5-HT and NA reuptake inhibitor (SNRI)
Alternative Names: BTS 54-524
Chemical Name: 1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for Sibutramine hydrochloride

Sibutramine hydrochloride is a 5-HT and noradrenalin re-uptake inhibitor (SNRI). Produces weight loss in rats via inhibition of food intake and increased energy expenditure. Antidepressant.

Technical Data for Sibutramine hydrochloride

M. Wt 316.31
Formula C17H26NCl.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 84485-00-7
PubChem ID 64764
Smiles ClC1=CC=C(C2(CCC2)C(CC(C)C)N(C)C)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Sibutramine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 1.58 5
DMSO 31.63 100

Preparing Stock Solutions for Sibutramine hydrochloride

The following data is based on the product molecular weight 316.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.81 mL 31.61 mL
5 mM 0.63 mL 3.16 mL 6.32 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets for Sibutramine hydrochloride

Certificate of Analysis / Product Datasheet
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References for Sibutramine hydrochloride

References are publications that support the biological activity of the product.

Jackson et al (1997) Comparison of the effects of sibutr. and other monoamine reuptake inhibitors on food intake in the rat. Br.J.Pharmacol. 121 1758 PMID: 9283714

Gundlah et al (1997) In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutr. is a reuptake inhibitor. J.Pharmacol.Exp.Ther. 283 581 PMID: 9353373

Buckett et al (1988) The pharmacology of sibutr. hydrochloride (BTS 54524), a new antidepressant which induces rapid noradrenergic down-regulation. Prog.Neuro-Psychopharm.Biol.Psychiat. 12 575

If you know of a relevant reference for Sibutramine hydrochloride, please let us know.

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1 Citation for Sibutramine hydrochloride

Citations are publications that use Tocris products. Selected citations for Sibutramine hydrochloride include:

Yoshida et al (2015) Study on health hazards through medicines purchased on the Internet: a cross-sectional investigation of the quality of anti-obesity medicines containing crude drugs as active ingredients. PLoS One 15 430 PMID: 26637485

Do you know of a great paper that uses Sibutramine hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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