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5-HT and noradrenalin re-uptake inhibitor (SNRI). Produces weight loss in rats via inhibition of food intake and increased energy expenditure. Antidepressant.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 316.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.16 mL||15.81 mL||31.61 mL|
|5 mM||0.63 mL||3.16 mL||6.32 mL|
|10 mM||0.32 mL||1.58 mL||3.16 mL|
|50 mM||0.06 mL||0.32 mL||0.63 mL|
References are publications that support the biological activity of the product.
Jackson et al (1997) Comparison of the effects of sibutr. and other monoamine reuptake inhibitors on food intake in the rat. Br.J.Pharmacol. 121 1758 PMID: 9283714
Gundlah et al (1997) In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutr. is a reuptake inhibitor. J.Pharmacol.Exp.Ther. 283 581 PMID: 9353373
Buckett et al (1988) The pharmacology of sibutr. hydrochloride (BTS 54524), a new antidepressant which induces rapid noradrenergic down-regulation. Prog.Neuro-Psychopharm.Biol.Psychiat. 12 575
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Keywords: Sibutramine hydrochloride, Sibutramine hydrochloride supplier, 5-HT, noradrenalin, reuptake, inhibitors, inhibits, SNRI, Noradrenalin, Transporter, NET, Adrenergic, Transporters, Monoamine, Neurotransmitter, Serotonin, SERT, 5-Hydroxytryptamine, BTS54524, noradrenaline, BTS, 54-524, 2290, Tocris Bioscience
1 Citation for Sibutramine hydrochloride
Citations are publications that use Tocris products. Selected citations for Sibutramine hydrochloride include:
Yoshida et al (2015) Study on health hazards through medicines purchased on the Internet: a cross-sectional investigation of the quality of anti-obesity medicines containing crude drugs as active ingredients. PLoS One 15 430 PMID: 26637485
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.