Sibutramine hydrochloride

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Cat.No. 2290 - Sibutramine hydrochloride | C17H26NCl.HCl | CAS No. 84485-00-7
Description: 5-HT and noradrenalin re-uptake inhibitor (SNRI)
Alternative Names: BTS 54-524
Chemical Name: 1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine hydrochloride
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

5-HT and noradrenalin re-uptake inhibitor (SNRI). Produces weight loss in rats via inhibition of food intake and increased energy expenditure. Antidepressant.

Technical Data

M. Wt 316.31
Formula C17H26NCl.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 84485-00-7
PubChem ID 64764
Smiles ClC1=CC=C(C2(CCC2)C(CC(C)C)N(C)C)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.63 100
water 1.58 5

Preparing Stock Solutions

The following data is based on the product molecular weight 316.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.81 mL 31.61 mL
5 mM 0.63 mL 3.16 mL 6.32 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Jackson et al (1997) Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat. Br.J.Pharmacol. 121 1758 PMID: 9283714

Gundlah et al (1997) In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor. J.Pharmacol.Exp.Ther. 283 581 PMID: 9353373

Buckett et al (1988) The pharmacology of sibutramine hydrochloride (BTS 54524), a new antidepressant which induces rapid noradrenergic down-regulation. Prog.Neuro-Psychopharm.Biol.Psychiat. 12 575 PMID:

If you know of a relevant reference for Sibutramine hydrochloride, please let us know.

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1 Citation for Sibutramine hydrochloride

Citations are publications that use Tocris products. Selected citations for Sibutramine hydrochloride include:

Yoshida et al (2015) Study on health hazards through medicines purchased on the Internet: a cross-sectional investigation of the quality of anti-obesity medicines containing crude drugs as active ingredients. PLoS One 15 430 PMID: 26637485

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