Sibutramine hydrochloride

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Cat.No. 2290 - Sibutramine hydrochloride | C17H26NCl.HCl | CAS No. 84485-00-7
Description: 5-HT and noradrenalin re-uptake inhibitor (SNRI)
Alternative Names: BTS 54-524
Chemical Name: 1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

5-HT and noradrenalin re-uptake inhibitor (SNRI). Produces weight loss in rats via inhibition of food intake and increased energy expenditure. Antidepressant.

Technical Data

M. Wt 316.31
Formula C17H26NCl.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 84485-00-7
PubChem ID 64764
InChI Key UWAOJIWUVCMBAZ-UHFFFAOYSA-N
Smiles ClC1=CC=C(C2(CCC2)C(CC(C)C)N(C)C)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.63 100
water 1.58 5

Preparing Stock Solutions

The following data is based on the product molecular weight 316.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.81 mL 31.61 mL
5 mM 0.63 mL 3.16 mL 6.32 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Jackson et al (1997) Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat. Br.J.Pharmacol. 121 1758 PMID: 9283714

Gundlah et al (1997) In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor. J.Pharmacol.Exp.Ther. 283 581 PMID: 9353373

Buckett et al (1988) The pharmacology of sibutramine hydrochloride (BTS 54524), a new antidepressant which induces rapid noradrenergic down-regulation. Prog.Neuro-Psychopharm.Biol.Psychiat. 12 575 PMID:


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View Related Products by Product Action

View all 5-HT Transporter Inhibitors

Keywords: 5-HT noradrenalin reuptake inhibitors inhibits SNRI Noradrenalin Transporter NET Adrenergic Transporters Monoamine Neurotransmitter Serotonin SERT 5-Hydroxytryptamine BTS54524 noradrenaline BTS 54-524 5-HT Transporters

1 Citation for Sibutramine hydrochloride

Citations are publications that use Tocris products. Selected citations for Sibutramine hydrochloride include:

Yoshida et al (2015) Study on health hazards through medicines purchased on the Internet: a cross-sectional investigation of the quality of anti-obesity medicines containing crude drugs as active ingredients. PLoS One 15 430 PMID: 26637485


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Literature in this Area

Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Pathways for Sibutramine hydrochloride

Protocols

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