BRL 52537 hydrochloride

Pricing Availability   Qty
Description: Potent and selective κ agonist
Chemical Name: (±)-1-(3,4-Dichlorophenyl)acetyl-2-(1-pyrrolidinyl)methylpiperidine hydrochloride
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for BRL 52537 hydrochloride

The most κ/μ-selective and among the most potent κ ligands known (25 times more potent than morphine in vivo).

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data for BRL 52537 hydrochloride

M. Wt 391.77
Formula C18H24Cl2N2O.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 112282-24-3
PubChem ID 11315337

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BRL 52537 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 1.96 5 with gentle warming

Preparing Stock Solutions for BRL 52537 hydrochloride

The following data is based on the product molecular weight 391.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 51.05 mL 255.25 mL 510.5 mL
0.25 mM 10.21 mL 51.05 mL 102.1 mL
0.5 mM 5.11 mL 25.53 mL 51.05 mL
2.5 mM 1.02 mL 5.11 mL 10.21 mL

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Product Datasheets for BRL 52537 hydrochloride

References for BRL 52537 hydrochloride

References are publications that support the biological activity of the product.

Vecchietti et al (1991) (2S)-1-(Arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective κ opioid analgesics. J.Med.Chem. 34 397 PMID: 1846921

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1 Citation for BRL 52537 hydrochloride

Citations are publications that use Tocris products. Selected citations for BRL 52537 hydrochloride include:

Morse et al (2013) Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family. BMC Pharmacol Toxicol 14 17 PMID: 23497702

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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