BRL 52537 hydrochloride
The most κ/μ-selective and among the most potent κ ligands known (25 times more potent than morphine in vivo).
Sold with the permission of GlaxoSmithKline
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||1.96||5 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 391.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||51.05 mL||255.25 mL||510.5 mL|
|0.25 mM||10.21 mL||51.05 mL||102.1 mL|
|0.5 mM||5.11 mL||25.53 mL||51.05 mL|
|2.5 mM||1.02 mL||5.11 mL||10.21 mL|
References are publications that support the biological activity of the product.
Vecchietti et al (1991) (2S)-1-(Arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective κ opioid analgesics. J.Med.Chem. 34 397 PMID: 1846921
If you know of a relevant reference for BRL 52537 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: BRL 52537 hydrochloride, BRL 52537 hydrochloride supplier, Potent, selective, κ-opioid, kappa-opioid, agonist, agonists, KOP, Receptors, OP2, BRL52537, hydrochloride, GlaxoSmithKline, GSK, Kappa, Opioid, 0699, Tocris Bioscience
1 Citation for BRL 52537 hydrochloride
Citations are publications that use Tocris products. Selected citations for BRL 52537 hydrochloride include:
Morse et al (2013) Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family. BMC Pharmacol Toxicol 14 17 PMID: 23497702
Do you know of a great paper that uses BRL 52537 hydrochloride from Tocris? Please let us know.
Reviews for BRL 52537 hydrochloride
There are currently no reviews for this product. Be the first to review BRL 52537 hydrochloride and earn rewards!
Have you used BRL 52537 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.