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BRL 52537 hydrochloride
Biological Activity for BRL 52537 hydrochloride
The most κ/μ-selective and among the most potent κ ligands known (25 times more potent than morphine in vivo).
Sold with the permission of GlaxoSmithKline
Technical Data for BRL 52537 hydrochloride
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BRL 52537 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||1.96||5 with gentle warming|
Preparing Stock Solutions for BRL 52537 hydrochloride
The following data is based on the product molecular weight 391.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||51.05 mL||255.25 mL||510.5 mL|
|0.25 mM||10.21 mL||51.05 mL||102.1 mL|
|0.5 mM||5.11 mL||25.53 mL||51.05 mL|
|2.5 mM||1.02 mL||5.11 mL||10.21 mL|
Product Datasheets for BRL 52537 hydrochloride
References for BRL 52537 hydrochloride
References are publications that support the biological activity of the product.
Vecchietti et al (1991) (2S)-1-(Arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective κ opioid analgesics. J.Med.Chem. 34 397 PMID: 1846921
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1 Citation for BRL 52537 hydrochloride
Citations are publications that use Tocris products. Selected citations for BRL 52537 hydrochloride include:
Morse et al (2013) Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family. BMC Pharmacol Toxicol 14 17 PMID: 23497702
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.