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Bretazenil is a partial agonist at the GABAA benzodiazepine site (EC50 = 10 nM at α1β1γ2 receptors). Displays anticonvulsive activity in vivo.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 418.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.39 mL||11.95 mL||23.91 mL|
|5 mM||0.48 mL||2.39 mL||4.78 mL|
|10 mM||0.24 mL||1.2 mL||2.39 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the biological activity of the product.
Rundfeldt et al (1995) Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of D.pam, bretazenil and abecarnil. J.Pharmacol.Exp.Ther. 275 693 PMID: 7473156
Munro et al (2008) Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with D.pam, zolpidem, bretazenil, and gaboxadol in rat models of i J.Pharmacol.Exp.Ther. 327 969 PMID: 18791060
Puia et al (1992) Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at γ-aminobutyric acid type A receptor. Proc.Natl.Acad.Sci. USA Neurobiology 89 3620
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Keywords: Bretazenil, Bretazenil supplier, benzodiazepines, partial, agonists, GABAA, receptors, Ro16-6028, Ro, 16-6028, Receptors, 3568, Tocris Bioscience
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