BRD 7116

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Cat.No. 5336 - BRD 7116 | C28H36N2O4S | CAS No. 329059-55-4
Description: Inhibitor of leukemia stem cell activity
Chemical Name: N,N'-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethylcyclopropanecarboxamide]
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity

Inhibitor of leukemia stem cell (LSC) activity (EC50 = 200 nM). Exhibits >100-fold selectivity for LSCs over normal hematopoietic stem cells.

Technical Data

M. Wt 496.66
Formula C28H36N2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 329059-55-4
PubChem ID 981129
Smiles O=C(C1C(C)(C)C1(C)C)NC(C=C2)=CC=C2S(C3=CC=C(NC(C4C(C)(C)C4(C)C)=O)C=C3)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.67 100
ethanol 9.93 20

Preparing Stock Solutions

The following data is based on the product molecular weight 496.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.07 mL 20.13 mL
5 mM 0.4 mL 2.01 mL 4.03 mL
10 mM 0.2 mL 1.01 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References are publications that support the biological activity of the product.

Hartwell et al (2013) Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nat.Chem.Biol. 9 840 PMID: 24161946

If you know of a relevant reference for BRD 7116, please let us know.

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Literature in this Area

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