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Inhibitor of leukemia stem cell (LSC) activity (EC50 = 200 nM). Exhibits >100-fold selectivity for LSCs over normal hematopoietic stem cells.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Hartwell et al (2013) Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nat.Chem.Biol. 9 840 PMID: 24161946
Keywords: BRD 7116, BRD 7116 supplier, BRD7116, leukemia, stem, cells, inhibitors, inhibits, LSCs, Cancer, Stem, Cells, 5336, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.