BRD 7116

Pricing Availability Delivery Time Qty
Cat.No. 5336 - BRD 7116 | C28H36N2O4S | CAS No. 329059-55-4
Description: Inhibitor of leukemia stem cell activity
Chemical Name: N,N'-(Sulfonyldi-4,1-phenylene)bis[2,2,3,3-tetramethylcyclopropanecarboxamide]
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of leukemia stem cell (LSC) activity (EC50 = 200 nM). Exhibits >100-fold selectivity for LSCs over normal hematopoietic stem cells.

Technical Data

M. Wt 496.66
Formula C28H36N2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 329059-55-4
PubChem ID 981129
InChI Key UHXFWAHRAMUDLJ-UHFFFAOYSA-N
Smiles O=C(C1C(C)(C)C1(C)C)NC(C=C2)=CC=C2S(C3=CC=C(NC(C4C(C)(C)C4(C)C)=O)C=C3)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.67 100
ethanol 9.93 20

Preparing Stock Solutions

The following data is based on the product molecular weight 496.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.07 mL 20.13 mL
5 mM 0.4 mL 2.01 mL 4.03 mL
10 mM 0.2 mL 1.01 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hartwell et al (2013) Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nat.Chem.Biol. 9 840 PMID: 24161946


If you know of a relevant reference for BRD 7116, please let us know.

View Related Products by Target

Keywords: BRD7116 leukemia stem cells inhibitors inhibits LSCs Cancer Stem Cells

Citations for BRD 7116

Citations are publications that use Tocris products.

Currently there are no citations for BRD 7116. Do you know of a great paper that uses BRD 7116 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Pathways for BRD 7116

Protocols

TODO: Add Protocols