Selective RARγ agonist (EC50 values are 30 and 1000 nM at RARγ and RARβ respectively). Displays no activity at RARα receptors.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 399.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.5 mL||12.52 mL||25.03 mL|
|5 mM||0.5 mL||2.5 mL||5.01 mL|
|10 mM||0.25 mL||1.25 mL||2.5 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Abu-Abed et al (1998) Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor γ and retinoid X receptor α. J.Biol.Chem. 273 2409 PMID: 9442090
Taneja et al (1996) Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc.Natl.Acad.Sci.USA 93 6197 PMID:
If you know of a relevant reference for BMS 961, please let us know.
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Keywords: BMS961 retinoic acid receptors retinoids rar rarg rargamma rarγ agonists selective Retinoic Acid Receptors
2 Citations for BMS 961
Citations are publications that use Tocris products. Selected citations for BMS 961 include:
Chronopoulos et al (2016) ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion Nature Communications 7 12630 PMID: 27600527
Centritto et al (2015) Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression. PLoS Pathog 7 950 PMID: 25888236
Do you know of a great paper that uses BMS 961 from Tocris? If so please let us know.