BMS 961

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Cat.No. 3410 - BMS 961 | C23H26FNO4 | CAS No. 185629-22-5
Description: Selective RARγ agonist
Chemical Name: 3-Fluoro-4-[[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-2-naphthalenyl)acetyl]amino]-benzoic acid
Purity: ≥97% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Selective RARγ agonist (EC50 values are 30 and 1000 nM at RARγ and RARβ respectively). Displays no activity at RARα receptors.

Technical Data

M. Wt 399.46
Formula C23H26FNO4
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 185629-22-5
PubChem ID 2418
InChI Key AANFHDFOMFRLLR-UHFFFAOYSA-N
Smiles CC1(C)C2=C(C=CC(C(O)C(NC3=CC=C(C(O)=O)C=C3F)=O)=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.95 100

Preparing Stock Solutions

The following data is based on the product molecular weight 399.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.52 mL 25.03 mL
5 mM 0.5 mL 2.5 mL 5.01 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Abu-Abed et al (1998) Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor γ and retinoid X receptor α. J.Biol.Chem. 273 2409 PMID: 9442090

Taneja et al (1996) Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc.Natl.Acad.Sci.USA 93 6197 PMID:

Klaholz et al (2000) Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγ. Proc.Natl.Acad.Sci. 97 6322 PMID:


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Keywords: BMS 961, supplier, BMS961, retinoic, acid, receptors, retinoids, rar, rarg, rargamma, rarγ, agonists, selective, Retinoic, Acid, Receptors, Retinoic, Acid, Receptors, Tocris Bioscience

2 Citations for BMS 961

Citations are publications that use Tocris products. Selected citations for BMS 961 include:

Chronopoulos et al (2016) ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion Nature Communications 7 12630 PMID: 27600527

Centritto et al (2015) Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARĪ± expression. PLoS Pathog 7 950 PMID: 25888236


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Pathways for BMS 961

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