BMS 961

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Cat.No. 3410 - BMS 961 | C23H26FNO4 | CAS No. 185629-22-5
Description: Selective RARγ agonist
Chemical Name: 3-Fluoro-4-[[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-2-naphthalenyl)acetyl]amino]-benzoic acid
Purity: ≥97% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (3)

Biological Activity

Selective RARγ agonist (EC50 values are 30 and 1000 nM at RARγ and RARβ respectively). Displays no activity at RARα receptors.

Compound Libraries

BMS 961 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 399.46
Formula C23H26FNO4
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 185629-22-5
PubChem ID 2418
InChI Key AANFHDFOMFRLLR-UHFFFAOYSA-N
Smiles CC1(C)C2=C(C=CC(C(O)C(NC3=CC=C(C(O)=O)C=C3F)=O)=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.95 100

Preparing Stock Solutions

The following data is based on the product molecular weight 399.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.52 mL 25.03 mL
5 mM 0.5 mL 2.5 mL 5.01 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Abu-Abed et al (1998) Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor γ and retinoid X receptor α. J.Biol.Chem. 273 2409 PMID: 9442090

Taneja et al (1996) Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc.Natl.Acad.Sci.USA 93 6197

Klaholz et al (2000) Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγ. Proc.Natl.Acad.Sci. 97 6322


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Keywords: BMS 961, BMS 961 supplier, BMS961, retinoic, acid, receptors, retinoids, rar, rarg, rargamma, rarγ, agonists, selective, Retinoic, Acid, Receptors, 3410, Tocris Bioscience

3 Citations for BMS 961

Citations are publications that use Tocris products. Selected citations for BMS 961 include:

Centritto et al (2015) Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression. PLoS Pathog 7 950 PMID: 25888236

Chronopoulos et al (2016) ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion Nature Communications 7 12630 PMID: 27600527

Wang et al (2016) Effects of retinoic acid receptor-γ on the Aspergillus fumigatus induced innate immunity response in human corneal epithelial cells. Int J Ophthalmol 9 1713 PMID: 28003968


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Literature in this Area

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