BMS 753

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Cat.No. 3505 - BMS 753 | C21H21NO4 | CAS No. 215307-86-1
Description: RARα-selective agonist
Chemical Name: 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

RARα-selective agonist (Ki = 2 nM).

Technical Data

M. Wt 351.4
Formula C21H21NO4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 215307-86-1
PubChem ID 9884820
InChI Key KFBPBWUZXBYJDG-UHFFFAOYSA-N
Smiles O=C1C(C)(C)C2=C(C=CC(C(NC3=CC=C(C(O)=O)C=C3)=O)=C2)C(C)1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.14 100
ethanol 35.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 351.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.23 mL 28.46 mL
5 mM 0.57 mL 2.85 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Gehin et al (1999) Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem.Biol. 6 519 PMID: 10421757

Taneja et al (1996) Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc.Natl.Acad.Sci.USA 93 6197

Dilworth et al (1999) Ligand-dependent activation of transcription in vitro by retinoid acid receptor α/retinoid X receptor α heterodimers that mimics transactivation by retinoids in vivo. Proc.Natl.Acad.Sci.USA 96 1995


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Keywords: BMS 753, BMS 753 supplier, retinoic, acid, agonists, rara, raralpha, rar-α, selective, BMS753, Retinoic, Acid, Receptors, 3505, Tocris Bioscience

1 Citation for BMS 753

Citations are publications that use Tocris products. Selected citations for BMS 753 include:

Raverdeau et al (2012) Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis. Proc Natl Acad Sci U S A 109 16582 PMID: 23012458


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Literature in this Area

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