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Biological Activity for BMS 753
BMS 753 is a RARα-selective agonist (Ki = 2 nM).
Compound Libraries for BMS 753
Technical Data for BMS 753
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BMS 753
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BMS 753
The following data is based on the product molecular weight 351.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.85 mL||14.23 mL||28.46 mL|
|5 mM||0.57 mL||2.85 mL||5.69 mL|
|10 mM||0.28 mL||1.42 mL||2.85 mL|
|50 mM||0.06 mL||0.28 mL||0.57 mL|
References for BMS 753
References are publications that support the biological activity of the product.
Gehin et al (1999) Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem.Biol. 6 519 PMID: 10421757
Taneja et al (1996) Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc.Natl.Acad.Sci.USA 93 6197 PMID: 8650243
Dilworth et al (1999) Ligand-dependent activation of transcription in vitro by retinoid acid receptor α/retinoid X receptor α heterodimers that mimics transactivation by retinoids in vivo. Proc.Natl.Acad.Sci.USA 96 1995 PMID: 10051583
If you know of a relevant reference for BMS 753, please let us know.
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Keywords: BMS 753, BMS 753 supplier, retinoic, acid, agonists, rara, raralpha, rar-α, selective, BMS753, Retinoic, Acid, Receptors, 3505, Tocris Bioscience
3 Citations for BMS 753
Citations are publications that use Tocris products. Selected citations for BMS 753 include:
Raverdeau et al (2012) Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis. Proc Natl Acad Sci U S A 109 16582 PMID: 23012458
Yuan et al (2019) Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology. Immunity 50 106-120.e10 PMID: 30650370
Vincent M et al (2022) Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models. J Tissue Eng 13 20417314221127908 PMID: 36277058
Do you know of a great paper that uses BMS 753 from Tocris? Please let us know.
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Literature in this Area
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