BMS 753

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Description: RARα-selective agonist
Chemical Name: 4-[[(2,3-Dihydro-1,1,3,3-tetramethyl-2-oxo-1H-inden-5-yl)carbonyl]amino]benzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (1)

Biological Activity for BMS 753

BMS 753 is a RARα-selective agonist (Ki = 2 nM).

Compound Libraries for BMS 753

BMS 753 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BMS 753

M. Wt 351.4
Formula C21H21NO4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 215307-86-1
PubChem ID 9884820
InChI Key KFBPBWUZXBYJDG-UHFFFAOYSA-N
Smiles O=C1C(C)(C)C2=C(C=CC(C(NC3=CC=C(C(O)=O)C=C3)=O)=C2)C(C)1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BMS 753

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.14 100
ethanol 35.14 100

Preparing Stock Solutions for BMS 753

The following data is based on the product molecular weight 351.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.23 mL 28.46 mL
5 mM 0.57 mL 2.85 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References for BMS 753

References are publications that support the biological activity of the product.

Gehin et al (1999) Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem.Biol. 6 519 PMID: 10421757

Taneja et al (1996) Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc.Natl.Acad.Sci.USA 93 6197 PMID: 8650243

Dilworth et al (1999) Ligand-dependent activation of transcription in vitro by retinoid acid receptor α/retinoid X receptor α heterodimers that mimics transactivation by retinoids in vivo. Proc.Natl.Acad.Sci.USA 96 1995 PMID: 10051583


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Keywords: BMS 753, BMS 753 supplier, retinoic, acid, agonists, rara, raralpha, rar-α, selective, BMS753, Retinoic, Acid, Receptors, 3505, Tocris Bioscience

3 Citations for BMS 753

Citations are publications that use Tocris products. Selected citations for BMS 753 include:

Yuan et al (2019) Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology. Immunity 50 106-120.e10 PMID: 30650370

Raverdeau et al (2012) Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis. Proc Natl Acad Sci U S A 109 16582 PMID: 23012458

Vincent M et al (2022) Molecular and electrophysiological evaluation of human cardiomyocyte subtypes to facilitate generation of composite cardiac models. J Tissue Eng 13 20417314221127908 PMID: 36277058


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Reviews for BMS 753

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.