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Provides a convenient non-isotopic alternative to radiolabeled NAD+ for determination of IC50 values for candidate PARP inhibitors and studies requiring this substrate. Biotinylated-NAD+ allows an indirect measure of PARP activity when biotin incorporation is detected using a conjugated-streptavidin detection system. Acts as a substrate for ADP-ribosylation. Can be used to label and purify biotinyl-ADP ribosylated proteins.
This product is a replacement for R&D Systems product 4670-500-01.
131 μg is supplied as 500 μl of a 0.25 mM solution in water.
|Storage||Store at -80°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble in water (supplied pre-dissolved at a concentration of 0.25mM)|
References are publications that support the biological activity of the product.
Zhang et al (1993) Purification of a nitric oxide-stimulated ADP-ribosylated protein using biotinylated beta-nicotinamide adenine dinucleotide. Biochemistry 32 2228 PMID: 8443164
Yang et al (2017) Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9 Mol. Cell 66 613 PMID: 28525742
Schuster et al (2017) The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells. Sci.Rep. 7 613 PMID: 28377614
Yang (2013) Antitumor activity of a pyrrole-imidazole polyamide. Proc.Natl.Acad.Sci.USA 110 1863 PMID: 23319609
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Keywords: Biotin-NAD+, Biotin-NAD+ supplier, 6-Biotin-17-NAD, 6-Biotin-10-NAD, Biotin-NAD+, Biotinylated-NAD, ADP-ribosylation, substrates, PARP, Biochemicals, and, Molecular, Biology, 6573, Tocris Bioscience
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