Bifemelane hydrochloride

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Cat.No. 0767 - Bifemelane hydrochloride | C18H23NO.HCl | CAS No. 62232-46-6
Description: MAO-A and MAO-B inhibitor
Chemical Name: 4-(2-Benzylphenoxy)-N-methylbutylamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Antidepressant MAO inhibitor. Reverses catalepsy induced by tetrabenazine in mice and increases locomotor activity in MPTP-treated marmosets.

Compound Libraries

Bifemelane hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 305.84
Formula C18H23NO.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 62232-46-6
PubChem ID 43962
InChI Key MEAHDXWXNNDSAK-UHFFFAOYSA-N
Smiles Cl.CNCCCCOC1=CC=CC=C1CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.58 100
water 30.58 100

Preparing Stock Solutions

The following data is based on the product molecular weight 305.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.27 mL 16.35 mL 32.7 mL
5 mM 0.65 mL 3.27 mL 6.54 mL
10 mM 0.33 mL 1.63 mL 3.27 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Naoi et al (1988) 4-(o-benzylphenoxy)-N-methylbutylamine (bifemelane) and other 4-(o-benzylphenoxy)-N-methylalkylamines as new inhibitors of type A and B monoamine oxidase. J.Neurochem. 50 243 PMID: 3335842

Nomoto et al (1994) Effects of bifemelane on parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the common marmoset. Neurosci.Lett. 178 95 PMID: 7816348

Tobe et al (1981) Pharmacological evaluation of 2-(4-methylaminobutoxy)diphenylmethane hydrochloride (MCl-2016), a new psychotropic drug with antidepressant activity. Arzneimittelforschung 31 1278 PMID: 7197535


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Keywords: MAO-A MAO-B inhibitors inhibits Monoamine oxygenases Oxidases Monoamine Oxidase

Citations for Bifemelane hydrochloride

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