BF 738735

Discontinued Product

BF 738735 (Cat. No. 6246) has been withdrawn from sale for commercial reasons.
Description: Potent and selective PI 4-kinase IIIβ inhibitor; broad spectrum enterovirus replication inhibitor
Chemical Name: 2-Fluoro-4-[2-methyl-8-[[[3-(methylsulfonyl)phenyl]methyl]amino]imidazo[1,2-a]pyrazin-3-yl]phenol
Purity: ≥98% (HPLC)

Biological Activity for BF 738735

BF 738735 is a potent and selective ATP-competitive phosphatidylinositol 4-kinase III beta (PI 4-KIIIβ) inhibitor (IC50 = 5.7 nM). Displays approximately 200-fold selectivity over PI 4-KIIIα. Broad spectrum enterovirus replication inhibitor.

Technical Data for BF 738735

M. Wt 426.47
Formula C21H19FN4O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1436383-95-7
PubChem ID 135742054
Smiles CC1=C(C2=CC(F)=C(C=C2)O)N3C=CN=C(C3=N1)NCC4=CC(S(C)(=O)=O)=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for BF 738735

References are publications that support the biological activity of the product.

MacLeod et al (2013) Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections. ACS Med.Chem.Lett. 4 585 PMID: 24900715

van der Schaar et al (2013) A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase III. Antimicrob.Agents Chemother. 57 4971

View Related Products by Target

View Related Products by Product Action

View all Other Kinase Inhibitors

Keywords: BF 738735, BF 738735 supplier, BF738735, antiviral, inhibits, inhibitors, enteroviral, enterovirus, replication, Phosphatidylinositol, 4-kinase, beta, PI4K3b, PI4KIIIb, PI4K3beta, PI4KIIIbeta, Other, Kinases, Antivirals, 6246, Tocris Bioscience

Citations for BF 738735

Citations are publications that use Tocris products.

Currently there are no citations for BF 738735.

Reviews for BF 738735

There are currently no reviews for this product. Be the first to review BF 738735 and earn rewards!

Have you used BF 738735?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review