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BF 738735 is a potent and selective ATP-competitive phosphatidylinositol 4-kinase III beta (PI 4-KIIIβ) inhibitor (IC50 = 5.7 nM). Displays approximately 200-fold selectivity over PI 4-KIIIα. Broad spectrum enterovirus replication inhibitor.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 426.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.34 mL||11.72 mL||23.45 mL|
|5 mM||0.47 mL||2.34 mL||4.69 mL|
|10 mM||0.23 mL||1.17 mL||2.34 mL|
|50 mM||0.05 mL||0.23 mL||0.47 mL|
References are publications that support the biological activity of the product.
MacLeod et al (2013) Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections. ACS Med.Chem.Lett. 4 585 PMID: 24900715
van der Schaar et al (2013) A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase III. Antimicrob.Agents Chemother. 57 4971
If you know of a relevant reference for BF 738735, please let us know.
Keywords: BF 738735, BF 738735 supplier, BF738735, antiviral, inhibits, inhibitors, enteroviral, enterovirus, replication, Phosphatidylinositol, 4-kinase, beta, PI4K3b, PI4KIIIb, PI4K3beta, PI4KIIIbeta, Other, Kinases, Antivirals, 6246, Tocris Bioscience
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