BF 738735

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Cat.No. 6246 - BF 738735 | C21H19FN4O3S | CAS No. 1436383-95-7
Description: Potent and selective PI 4-kinase IIIβ inhibitor; broad spectrum enterovirus replication inhibitor
Chemical Name: 2-Fluoro-4-[2-methyl-8-[[[3-(methylsulfonyl)phenyl]methyl]amino]imidazo[1,2-a]pyrazin-3-yl]phenol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective ATP-competitive phosphatidylinositol 4-kinase III beta (PI 4-KIIIβ) inhibitor (IC50 = 5.7 nM). Displays approximately 200-fold selectivity over PI 4-KIIIα. Broad spectrum enterovirus replication inhibitor.

Technical Data

M. Wt 426.47
Formula C21H19FN4O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1436383-95-7
PubChem ID 135742054
InChI Key IMHZCCZYPHJVMS-UHFFFAOYSA-N
Smiles CC1=C(C2=CC(F)=C(C=C2)O)N3C=CN=C(C3=N1)NCC4=CC(S(C)(=O)=O)=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.65 100
ethanol 8.53 20

Preparing Stock Solutions

The following data is based on the product molecular weight 426.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.34 mL 11.72 mL 23.45 mL
5 mM 0.47 mL 2.34 mL 4.69 mL
10 mM 0.23 mL 1.17 mL 2.34 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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References

References are publications that support the biological activity of the product.

MacLeod et al (2013) Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections. ACS Med.Chem.Lett. 4 585 PMID: 24900715

van der Schaar et al (2013) A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase III. Antimicrob.Agents Chemother. 57 4971


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Keywords: BF 738735, BF 738735 supplier, BF738735, antiviral, inhibits, inhibitors, enteroviral, enterovirus, replication, Phosphatidylinositol, 4-kinase, beta, PI4K3b, PI4KIIIb, PI4K3beta, PI4KIIIbeta, Other, Kinases, Antivirals, 6246, Tocris Bioscience

Citations for BF 738735

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