BF 738735

Discontinued Product

BF 738735 (Cat. No. 6246) has been withdrawn from sale for commercial reasons.
Description: Potent and selective PI 4-kinase IIIβ inhibitor; broad spectrum enterovirus replication inhibitor
Chemical Name: 2-Fluoro-4-[2-methyl-8-[[[3-(methylsulfonyl)phenyl]methyl]amino]imidazo[1,2-a]pyrazin-3-yl]phenol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for BF 738735

BF 738735 is a potent and selective ATP-competitive phosphatidylinositol 4-kinase III beta (PI 4-KIIIβ) inhibitor (IC50 = 5.7 nM). Displays approximately 200-fold selectivity over PI 4-KIIIα. Broad spectrum enterovirus replication inhibitor.

Technical Data for BF 738735

M. Wt 426.47
Formula C21H19FN4O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1436383-95-7
PubChem ID 135742054
InChI Key IMHZCCZYPHJVMS-UHFFFAOYSA-N
Smiles CC1=C(C2=CC(F)=C(C=C2)O)N3C=CN=C(C3=N1)NCC4=CC(S(C)(=O)=O)=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for BF 738735

References are publications that support the biological activity of the product.

MacLeod et al (2013) Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections. ACS Med.Chem.Lett. 4 585 PMID: 24900715

van der Schaar et al (2013) A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase III. Antimicrob.Agents Chemother. 57 4971

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Keywords: BF 738735, BF 738735 supplier, BF738735, antiviral, inhibits, inhibitors, enteroviral, enterovirus, replication, Phosphatidylinositol, 4-kinase, beta, PI4K3b, PI4KIIIb, PI4K3beta, PI4KIIIbeta, Other, Kinases, Antivirals, 6246, Tocris Bioscience

Citations for BF 738735

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Currently there are no citations for BF 738735.

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