Benidipine hydrochloride

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Cat.No. 3934 - Benidipine hydrochloride | C28H31N3O6.HCl | CAS No. 91599-74-5
Description: Calcium channel blocker
Alternative Names: KW 3049
Chemical Name: (4R)-rel-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo. Inhibits L-, N- and T-type Ca2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.

Technical Data

M. Wt 542.02
Formula C28H31N3O6.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 91599-74-5
PubChem ID 76968919
InChI Key SPMJXDRNJQIBTB-IMEZZWDRSA-N
Smiles CC1=C(C(OC)=O)[C@@H]([C@]2=CC([N+]([O-])=O)=CC=C2)C(C(O[C@H]3CN(CC4=CC=CC=C4)CCC3)=O)=C(C)N1.CC5=C(C(OC)=O)[C@H]([C@]6=CC([N+]([O-])=O)=CC=C6)C(C(O[C@@H]7CN(CC8=CC=CC=C8)CCC7)=O)=C(C)N5.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.65 75
ethanol 5.42 10

Preparing Stock Solutions

The following data is based on the product molecular weight 542.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.84 mL 9.22 mL 18.45 mL
5 mM 0.37 mL 1.84 mL 3.69 mL
10 mM 0.18 mL 0.92 mL 1.84 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Yao et al (2006) Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel long-acting calcium channel blocker. J.Pharmacol.Sci. 100 243 PMID: 16565579

Kosaka et al (2010) The L-, N-, T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family. Eur.J.Pharmacol. 635 49 PMID: 20307534


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Keywords: L-type T-type N-type calcium channels Ca2+ blockers inhibitors inhibits selective voltage-gated voltage-dependent CaV mineralocorticoid receptor antagonist KW3049 KW 3049 Voltage-gated Calcium Channels

Citations for Benidipine hydrochloride

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Literature in this Area

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Pathways for Benidipine hydrochloride

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