Benidipine hydrochloride

Discontinued Product

Benidipine hydrochloride (Cat. No. 3934) has been withdrawn from sale for commercial reasons.
Cat.No. 3934 - Benidipine hydrochloride | C28H31N3O6.HCl | CAS No. 91599-74-5
Description: Non-selective Cav blocker; also mineralocorticoid receptor antagonist
Alternative Names: KW 3049
Chemical Name: (4R)-rel-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester hydrochloride
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity for Benidipine hydrochloride

Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo. Inhibits L-, N- and T-type Ca2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.

Technical Data for Benidipine hydrochloride

M. Wt 542.02
Formula C28H31N3O6.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 91599-74-5
PubChem ID 76968919
Smiles CC1=C(C(OC)=O)[C@@H]([C@]2=CC([N+]([O-])=O)=CC=C2)C(C(O[C@H]3CN(CC4=CC=CC=C4)CCC3)=O)=C(C)N1.CC5=C(C(OC)=O)[C@H]([C@]6=CC([N+]([O-])=O)=CC=C6)C(C(O[C@@H]7CN(CC8=CC=CC=C8)CCC7)=O)=C(C)N5.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Benidipine hydrochloride

References for Benidipine hydrochloride

References are publications that support the biological activity of the product.

Yao et al (2006) Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel long-acting calcium channel blocker. J.Pharmacol.Sci. 100 243 PMID: 16565579

Kosaka et al (2010) The L-, N-, T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family. Eur.J.Pharmacol. 635 49 PMID: 20307534

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Keywords: Benidipine hydrochloride, Benidipine hydrochloride supplier, L-type, T-type, N-type, calcium, channels, Ca2+, blockers, inhibitors, inhibits, selective, voltage-gated, voltage-dependent, CaV, mineralocorticoid, receptor, antagonist, KW3049, KW, 3049, Non-selective, Cav, Channels, Mineralocorticoid, Receptor, 3934, Tocris Bioscience

1 Citation for Benidipine hydrochloride

Citations are publications that use Tocris products. Selected citations for Benidipine hydrochloride include:

Bhandage et al (2019) Toxoplasma-Induced Hypermigration of Primary Cortical Microglia Implicates GABAergic Signaling. Front Cell Infect Microbiol 9 73 PMID: 30949457

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