Benidipine hydrochloride

Pricing Availability   Qty
Cat.No. 3934 - Benidipine hydrochloride | C28H31N3O6.HCl | CAS No. 91599-74-5
Description: Non-selective Cav blocker; also mineralocorticoid receptor antagonist
Alternative Names: KW 3049
Chemical Name: (4R)-rel-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo. Inhibits L-, N- and T-type Ca2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.

Technical Data

M. Wt 542.02
Formula C28H31N3O6.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 91599-74-5
PubChem ID 76968919
InChI Key SPMJXDRNJQIBTB-IMEZZWDRSA-N
Smiles CC1=C(C(OC)=O)[C@@H]([C@]2=CC([N+]([O-])=O)=CC=C2)C(C(O[C@H]3CN(CC4=CC=CC=C4)CCC3)=O)=C(C)N1.CC5=C(C(OC)=O)[C@H]([C@]6=CC([N+]([O-])=O)=CC=C6)C(C(O[C@@H]7CN(CC8=CC=CC=C8)CCC7)=O)=C(C)N5.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.65 75
ethanol 5.42 10

Preparing Stock Solutions

The following data is based on the product molecular weight 542.02. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 2.46 mL 12.3 mL 24.6 mL
3.75 mM 0.49 mL 2.46 mL 4.92 mL
7.5 mM 0.25 mL 1.23 mL 2.46 mL
37.5 mM 0.05 mL 0.25 mL 0.49 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Yao et al (2006) Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel long-acting calcium channel blocker. J.Pharmacol.Sci. 100 243 PMID: 16565579

Kosaka et al (2010) The L-, N-, T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family. Eur.J.Pharmacol. 635 49 PMID: 20307534


If you know of a relevant reference for Benidipine hydrochloride, please let us know.

View Related Products by Product Action

View all Non-selective Cav Channel Blockers

Keywords: Benidipine hydrochloride, Benidipine hydrochloride supplier, L-type, T-type, N-type, calcium, channels, Ca2+, blockers, inhibitors, inhibits, selective, voltage-gated, voltage-dependent, CaV, mineralocorticoid, receptor, antagonist, KW3049, KW, 3049, Non-selective, Cav, Channels, Mineralocorticoid, Receptor, 3934, Tocris Bioscience

Citations for Benidipine hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Benidipine hydrochloride. Do you know of a great paper that uses Benidipine hydrochloride from Tocris? Please let us know.

Reviews for Benidipine hydrochloride

There are currently no reviews for this product. Be the first to review Benidipine hydrochloride and earn rewards!

Have you used Benidipine hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


New Product Guide

New Product Guide (Fall/Winter 2018/2019)

Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • PROTACs
  • Signal Transduction
  • Stem Cells