Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo. Inhibits L-, N- and T-type Ca2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 542.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.84 mL||9.22 mL||18.45 mL|
|5 mM||0.37 mL||1.84 mL||3.69 mL|
|10 mM||0.18 mL||0.92 mL||1.84 mL|
|50 mM||0.04 mL||0.18 mL||0.37 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Yao et al (2006) Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel long-acting calcium channel blocker. J.Pharmacol.Sci. 100 243 PMID: 16565579
Kosaka et al (2010) The L-, N-, T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family. Eur.J.Pharmacol. 635 49 PMID: 20307534
If you know of a relevant reference for Benidipine hydrochloride, please let us know.
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Keywords: L-type T-type N-type calcium channels Ca2+ blockers inhibitors inhibits selective voltage-gated voltage-dependent CaV mineralocorticoid receptor antagonist KW3049 KW 3049 Voltage-gated Calcium Channels
Citations for Benidipine hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Benidipine hydrochloride. Do you know of a great paper that uses Benidipine hydrochloride from Tocris? If so please let us know.
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