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Potent inhibitor of NF-κB activation (IC50 = 85 nM); decreases IκBα phosphorylation. Attenuates LPS-induced nitric oxide production and expression of TNF-α, IL-6 and MCP. Suppresses proliferation of HeLa and HCT116 cells. Anti-inflammatory and antitumor.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 598.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.02 mM||83.5 mL||417.49 mL||834.99 mL|
|0.1 mM||16.7 mL||83.5 mL||167 mL|
|0.2 mM||8.35 mL||41.75 mL||83.5 mL|
|1 mM||1.67 mL||8.35 mL||16.7 mL|
References are publications that support the biological activity of the product.
Hu et al (2007) Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem.Biol. 14 764 PMID: 17656313
Johnson et al (2012) Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries. Bioorg.Med.Chem. 20 4348 PMID: 22705020
Kinder et al (2001) Synthesis and antitumor activity of ester-modified analogues of bengamide B. J.Med.Chem. 44 3692 PMID: 11606134
If you know of a relevant reference for Bengamide B, please let us know.
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Keywords: Bengamide B, Bengamide B supplier, Methionyl, aminopeptidase, MetAP1, MetAP2, potent, NF-κB, inhibitors, nuclear, factor, kappa, B, anti-inflammatory, antitumor, antitumour, inhibits, NF-kB/IkB, 5273, Tocris Bioscience
Citations for Bengamide B
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Literature in this Area
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