BDY FL Lenalidomide

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Description: Fluorescent cereblon ligand
Chemical Name: 3-(5,5-Difluoro-7,9-dimethyl-5H-5λ4,6λ4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)hexyl)propanamide
Purity: ≥95% (HPLC)
Literature (2)

Biological Activity for BDY FL Lenalidomide

BDY FL Lenalidomide is a fluorescent cereblon ligand. It can be used in time-resolved fluorescence resonance energy-transfer (TR-FRET) cereblon binding assays for PROTAC® Degrader development. This assay is highly sensitive, selective, and stable. Excitation and emission maxima (λ) are 506 and 508 nm, respectively.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Optical Data for BDY FL Lenalidomide

BDY FL Lenalidomide Dye Spectra
Emission Color Green
λabs 506 nm
λem 508 nm
Closest Laser line 488 nm
Cell Permeable Yes
Application TR-FRET and FP Assays
Alternative For BDY FL Thalidomide

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Technical Data for BDY FL Lenalidomide

M. Wt 632.52
Formula C33H39BF2N6O4
Storage Store at -20°C
Purity ≥95% (HPLC)
Smiles O=C(CCC1N2C(C3=C(C2)C(NCCCCCCNC(CCC4=CC=C5N4[B-](F)([N+]6=C(C=C(C6=C5)C)C)F)=O)=CC=C3)=O)NC1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BDY FL Lenalidomide

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 6.33 10

Preparing Stock Solutions for BDY FL Lenalidomide

The following data is based on the product molecular weight 632.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.81 mL 79.05 mL 158.1 mL
0.5 mM 3.16 mL 15.81 mL 31.62 mL
1 mM 1.58 mL 7.9 mL 15.81 mL
5 mM 0.32 mL 1.58 mL 3.16 mL

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Product Datasheets for BDY FL Lenalidomide

References for BDY FL Lenalidomide

References are publications that support the biological activity of the product.

Wang et al (2021) Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat.Chem.Biol. 17 711 PMID: 34035522

If you know of a relevant reference for BDY FL Lenalidomide, please let us know.

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Citations for BDY FL Lenalidomide

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Literature in this Area

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