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Submit ReviewBDY FL Lenalidomide
Description: Fluorescent cereblon ligand
Chemical Name: 3-(5,5-Difluoro-7,9-dimethyl-5H-5λ4,6λ4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-3-yl)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)amino)hexyl)propanamide
Purity: ≥95% (HPLC)
Biological Activity for BDY FL Lenalidomide
BDY FL Lenalidomide is a fluorescent cereblon ligand. It can be used in time-resolved fluorescence resonance energy-transfer (TR-FRET) cereblon binding assays for PROTAC® Degrader development. This assay is highly sensitive, selective, and stable. Excitation and emission maxima (λ) are 506 and 508 nm, respectively.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Optical Data for BDY FL Lenalidomide
| Emission Color | Green |
|---|---|
| λabs | 506 nm |
| λem | 508 nm |
| Closest Laser line | 488 nm |
| Cell Permeable | Yes |
| Application | TR-FRET and FP Assays |
| Alternative For | BDY FL Thalidomide |
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
Spectral Viewer
Technical Data for BDY FL Lenalidomide
| M. Wt | 632.52 |
| Formula | C33H39BF2N6O4 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| InChI Key | RCUBMUCPIXRRKQ-UHFFFAOYSA-N |
| Smiles | O=C(CCC1N2C(C3=C(C2)C(NCCCCCCNC(CCC4=CC=C5N4[B-](F)([N+]6=C(C=C(C6=C5)C)C)F)=O)=CC=C3)=O)NC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for BDY FL Lenalidomide
References for BDY FL Lenalidomide
References are publications that support the biological activity of the product.
Wang et al (2021) Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat.Chem.Biol. 17 711 PMID: 34035522
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