Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewBAZ2-ICR
Description: Selective BAZ2 inhibitor
Chemical Name: 4-[4-(1-Methyl-1H-pyrazole-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]benzonitrile
Purity: ≥98% (HPLC)
Biological Activity for BAZ2-ICR
BAZ2-ICR is a selective BAZ2 bromodomain inhibitor (IC50 values are 130 and 180 nM for BAZ2A and BAZ2B respectively). Exhibits 15-fold selectivity for the BAZ2 bromodomain over the CERC2 bromodomain and >100-fold selectivity over a range of other bromodomains. Accelerates FRAP recovery in a BAZ2A FRAP assay.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAZ2-ICR probe summary on the SGC website.
External Portal Information for BAZ2-ICR
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAZ2-ICR is reviewed on the chemical probes website.
Compound Libraries for BAZ2-ICR
BAZ2-ICR is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for BAZ2-ICR
| M. Wt | 357.41 |
| Formula | C20H19N7 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1665195-94-7 |
| PubChem ID | 91654625 |
| InChI Key | RRZVGDGTWNQAPW-UHFFFAOYSA-N |
| Smiles | CN(N=C4)C=C4CCN1C=NC(C3=CN(C)N=C3)=C1C2=CC=C(C#N)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BAZ2-ICR
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.74 | 100 | |
| ethanol | 35.74 | 100 |
Preparing Stock Solutions for BAZ2-ICR
The following data is based on the product molecular weight 357.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.8 mL | 13.99 mL | 27.98 mL |
| 5 mM | 0.56 mL | 2.8 mL | 5.6 mL |
| 10 mM | 0.28 mL | 1.4 mL | 2.8 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for BAZ2-ICR
References for BAZ2-ICR
References are publications that support the biological activity of the product.
Drouin et al (2015) Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B. J.Med.Chem. 58 2553 PMID: 25719566
If you know of a relevant reference for BAZ2-ICR, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: BAZ2-ICR, BAZ2-ICR supplier, BAZ2-ICR, selective, baz2, bromodomains, inhibitors, inhibits, BAZ2A, BAZ2B, epigenetics, SGC, structural, genomics, consortium, Bromodomains, 5266, Tocris Bioscience
Citations for BAZ2-ICR
Citations are publications that use Tocris products.
Currently there are no citations for BAZ2-ICR. Do you know of a great paper that uses BAZ2-ICR from Tocris? Please let us know.
Reviews for BAZ2-ICR
There are currently no reviews for this product. Be the first to review BAZ2-ICR and earn rewards!
Have you used BAZ2-ICR?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Stem Cell Research Product GuideUpdated
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics in Cancer PosterUpdated
This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.