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Description: Selective BAZ2 inhibitor
Chemical Name: 4-[4-(1-Methyl-1H-pyrazole-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)ethyl]-1H-imidazol-5-yl]benzonitrile
Purity: ≥98% (HPLC)
Biological Activity for BAZ2-ICR
BAZ2-ICR is a selective BAZ2 bromodomain inhibitor (IC50 values are 130 and 180 nM for BAZ2A and BAZ2B respectively). Exhibits 15-fold selectivity for the BAZ2 bromodomain over the CERC2 bromodomain and >100-fold selectivity over a range of other bromodomains. Accelerates FRAP recovery in a BAZ2A FRAP assay.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAZ2-ICR probe summary on the SGC website.
External Portal Information for BAZ2-ICR
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAZ2-ICR is reviewed on the chemical probes website.
Compound Libraries for BAZ2-ICR
BAZ2-ICR is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for BAZ2-ICR
| M. Wt | 357.41 |
| Formula | C20H19N7 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1665195-94-7 |
| PubChem ID | 91654625 |
| InChI Key | RRZVGDGTWNQAPW-UHFFFAOYSA-N |
| Smiles | CN(N=C4)C=C4CCN1C=NC(C3=CN(C)N=C3)=C1C2=CC=C(C#N)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BAZ2-ICR
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.74 | 100 | |
| ethanol | 35.74 | 100 |
Preparing Stock Solutions for BAZ2-ICR
The following data is based on the product molecular weight 357.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.8 mL | 13.99 mL | 27.98 mL |
| 5 mM | 0.56 mL | 2.8 mL | 5.6 mL |
| 10 mM | 0.28 mL | 1.4 mL | 2.8 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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Product Datasheets for BAZ2-ICR
References for BAZ2-ICR
References are publications that support the biological activity of the product.
Drouin et al (2015) Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B. J.Med.Chem. 58 2553 PMID: 25719566
If you know of a relevant reference for BAZ2-ICR, please let us know.
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Citations for BAZ2-ICR
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