BAZ2-ICR
Biological Activity
Selective BAZ2 bromodomain inhibitor (IC50 values are 130 and 180 nM for BAZ2A and BAZ2B respectively). Exhibits 15-fold selectivity for the BAZ2 bromodomain over the CERC2 bromodomain and >100-fold selectivity over a range of other bromodomains. Accelerates FRAP recovery in a BAZ2A FRAP assay.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAZ2-ICR probe summary on the SGC website.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BAZ2-ICR is reviewed on the chemical probes website.
Compound Libraries
BAZ2-ICR is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 357.41 |
| Formula | C20H19N7 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 91654625 |
| InChI Key | RRZVGDGTWNQAPW-UHFFFAOYSA-N |
| Smiles | CN(N=C4)C=C4CCN1C=NC(C3=CN(C)N=C3)=C1C2=CC=C(C#N)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.74 | 100 | |
| ethanol | 35.74 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 357.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.8 mL | 13.99 mL | 27.98 mL |
| 5 mM | 0.56 mL | 2.8 mL | 5.6 mL |
| 10 mM | 0.28 mL | 1.4 mL | 2.8 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Drouin et al (2015) Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B. J.Med.Chem. 58 2553 PMID: 25719566
If you know of a relevant reference for BAZ2-ICR, please let us know.
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Keywords: BAZ2-ICR, supplier, BAZ2-ICR, selective, baz2, bromodomains, inhibitors, inhibits, BAZ2A, BAZ2B, epigenetics, SGC, structural, genomics, consortium, Bromodomains, Bromodomains, Tocris Bioscience
Citations for BAZ2-ICR
Citations are publications that use Tocris products.
Currently there are no citations for BAZ2-ICR. Do you know of a great paper that uses BAZ2-ICR from Tocris? If so please let us know.
Literature in this Area
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