BAY 87-2243

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Cat.No. 6980 - BAY 87-2243 | C26H26F3N7O2 | CAS No. 1227158-85-1
Description: Mitochondrial complex I inhibitor
Chemical Name: 1-Cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]piperazine
Purity: ≥98% (HPLC)

Biological Activity for BAY 87-2243

BAY 87-2243 is a mitochondrial complex I inhibitor. Exhibits no effect on mitochondrial complex III. Induces mitochondrial permeability transition pore (mPTP) opening, stimulates autophagosome formation and mitophagy, and increases ROS levels. Activates necroptotic and ferroptotic cell death. Also inhibits hypoxia-induced gene activation. Induces cell death in melanoma cell lines in vitro and exhibits antitumor activity in a mouse NSCLC xenograft model in vivo.

Compound Libraries for BAY 87-2243

BAY 87-2243 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BAY 87-2243

M. Wt 525.54
Formula C26H26F3N7O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1227158-85-1
PubChem ID 67377767
Smiles CC1=CC(=NN1CC1=CC=NC(=C1)N1CCN(CC1)C1CC1)C1=NC(=NO1)C1=CC=C(OC(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAY 87-2243

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.28 50
ethanol 10.51 20

Preparing Stock Solutions for BAY 87-2243

The following data is based on the product molecular weight 525.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.81 mL 19.03 mL 38.06 mL
2.5 mM 0.76 mL 3.81 mL 7.61 mL
5 mM 0.38 mL 1.9 mL 3.81 mL
25 mM 0.08 mL 0.38 mL 0.76 mL

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References for BAY 87-2243

References are publications that support the biological activity of the product.

Basit et al (2017) Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells. Cell Death Dis. 8 e2716 PMID: 28358377

Ellinghaus et al (2013) BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I. Cancer Med. 2 611 PMID: 24403227

If you know of a relevant reference for BAY 87-2243, please let us know.

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Keywords: BAY 87-2243, BAY 87-2243 supplier, BAY87-2243, Hypoxia, inducible, factor, HIF, 1alpha, alfa, mitochondrial, complex, I, inhibitors, inhibits, Oxidative, Phosphorylation, 6980, Tocris Bioscience

Citations for BAY 87-2243

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