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Submit ReviewB-HT 920
Description: D2 agonist; also α2-adrenoceptor agonist and 5-HT3 antagonist
Alternative Names: Talipexole
Chemical Name: 5,6,7,8-Tetrahydro-6-(2-propen-1-yl)-4H-thiazolo[4,5-d]azepin-2-amine dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity
Dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist. Displays antiParkinsonian activity.
Technical Data
| M. Wt | 282.23 |
| Formula | C10H15N3S.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 36085-73-1 |
| PubChem ID | 104870 |
| InChI Key | DPQAXNSOFFYKDS-UHFFFAOYSA-N |
| Smiles | Cl.Cl.NC1=NC2=C(CCN(CC=C)CC2)S1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 28.22 | 100 | |
| DMSO | 28.22 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 282.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.54 mL | 17.72 mL | 35.43 mL |
| 5 mM | 0.71 mL | 3.54 mL | 7.09 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.54 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
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References
References are publications that support the biological activity of the product.
Robertson et al (1993) In vivo comparisons of the effects of quinpirole and the putative presynaptic DArgic agonists B-HT 920 and SND 919 on striatal DA and acetylcholine release. J.Pharmacol.Exp.Ther. 264 1344 PMID: 8095550
Nishio et al (1996) 5-HT3 receptor blocking properties of the antiParkinsonian agent, talipexole. Gen.Pharmacol. 27 779 PMID: 8842679
Ricci and Taira (1999) Adrenoceptor involvement in the cardiovascular responses to B-HT 920 in sinoaortic denervated rats. Gen.Pharmacol. 32 29 PMID: 9888250
Maina and Mathews (2010) A functional fast scan cyclic voltammetry assay to characterize DA D2 and D3 autoreceptors in the mouse striatum. ACS Chem.Neurosci. 1 450 PMID: 20567609
If you know of a relevant reference for B-HT 920, please let us know.
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1 Citation for B-HT 920
Citations are publications that use Tocris products. Selected citations for B-HT 920 include:
Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Autophagy 7 2336 PMID: 26114334
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