B-HT 920
Biological Activity
Dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist. Displays antiParkinsonian activity.
Technical Data
| M. Wt | 282.23 |
| Formula | C10H15N3S.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 36085-73-1 |
| PubChem ID | 104870 |
| InChI Key | DPQAXNSOFFYKDS-UHFFFAOYSA-N |
| Smiles | Cl.Cl.NC1=NC2=C(CCN(CC=C)CC2)S1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.22 | 100 | |
| ethanol | 1.41 | 5 | |
| water | 28.22 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 282.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.54 mL | 17.72 mL | 35.43 mL |
| 5 mM | 0.71 mL | 3.54 mL | 7.09 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.54 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Robertson et al (1993) In vivo comparisons of the effects of quinpirole and the putative presynaptic dopaminergic agonists B-HT 920 and SND 919 on striatal dopamine and acetylcholine release. J.Pharmacol.Exp.Ther. 264 1344 PMID: 8095550
Nishio et al (1996) 5-HT3 receptor blocking properties of the antiParkinsonian agent, talipexole. Gen.Pharmacol. 27 779 PMID: 8842679
Ricci and Taira (1999) Adrenoceptor involvement in the cardiovascular responses to B-HT 920 in sinoaortic denervated rats. Gen.Pharmacol. 32 29 PMID: 9888250
Maina and Mathews (2010) A functional fast scan cyclic voltammetry assay to characterize dopamine D2 and D3 autoreceptors in the mouse striatum. ACS Chem.Neurosci. 1 450 PMID: 20567609
If you know of a relevant reference for B-HT 920, please let us know.
View Related Products by Target
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Keywords: 5-HT3 antagonists D2 α2-adrenoceptor alpha2-adrenoceptor a2-adrenoceptor a2-adrenergic agonists receptor Serotonin Receptors Dopamine dopaminergic B-HT920 Talipexole D2 Receptors
1 Citation for B-HT 920
Citations are publications that use Tocris products. Selected citations for B-HT 920 include:
Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Autophagy 7 2336 PMID: 26114334
Do you know of a great paper that uses B-HT 920 from Tocris? If so please let us know.
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