B-HT 920

Pricing Availability Delivery Time Qty
Cat.No. 2759 - B-HT 920 | C10H15N3S.2HCl | CAS No. 36085-73-1
Description: D2 receptor agonist. Also α2 agonist and 5-HT3 antagonist
Alternative Names: Talipexole
Chemical Name: 5,6,7,8-Tetrahydro-6-(2-propen-1-yl)-4H-thiazolo[4,5-d]azepin-2-amine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist. Displays antiParkinsonian activity.

Technical Data

M. Wt 282.23
Formula C10H15N3S.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 36085-73-1
PubChem ID 104870
InChI Key DPQAXNSOFFYKDS-UHFFFAOYSA-N
Smiles Cl.Cl.NC1=NC2=C(CCN(CC=C)CC2)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.22 100
ethanol 1.41 5
water 28.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 282.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.72 mL 35.43 mL
5 mM 0.71 mL 3.54 mL 7.09 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Robertson et al (1993) In vivo comparisons of the effects of quinpirole and the putative presynaptic dopaminergic agonists B-HT 920 and SND 919 on striatal dopamine and acetylcholine release. J.Pharmacol.Exp.Ther. 264 1344 PMID: 8095550

Nishio et al (1996) 5-HT3 receptor blocking properties of the antiParkinsonian agent, talipexole. Gen.Pharmacol. 27 779 PMID: 8842679

Ricci and Taira (1999) Adrenoceptor involvement in the cardiovascular responses to B-HT 920 in sinoaortic denervated rats. Gen.Pharmacol. 32 29 PMID: 9888250

Maina and Mathews (2010) A functional fast scan cyclic voltammetry assay to characterize dopamine D2 and D3 autoreceptors in the mouse striatum. ACS Chem.Neurosci. 1 450 PMID: 20567609


If you know of a relevant reference for B-HT 920, please let us know.

View Related Products by Product Action

View all D2 Receptor Agonists

Keywords: 5-HT3 antagonists D2 α2-adrenoceptor alpha2-adrenoceptor a2-adrenoceptor a2-adrenergic agonists receptor Serotonin Receptors Dopamine dopaminergic B-HT920 Talipexole D2 Receptors

1 Citation for B-HT 920

Citations are publications that use Tocris products. Selected citations for B-HT 920 include:

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Autophagy 7 2336 PMID: 26114334


Do you know of a great paper that uses B-HT 920 from Tocris? If so please let us know.

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Pathways for B-HT 920

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