AZ 12216052

Discontinued Product

AZ 12216052 (Cat. No. 4832) has been withdrawn from sale for commercial reasons.
Description: Positive allosteric modulator of mGlu8 receptors
Chemical Name: 2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide
Purity: ≥97% (HPLC)
Literature (4)

Biological Activity for AZ 12216052

AZ 12216052 is a positive allosteric modulator at mGlu8 receptors. Exhibits anxiolytic effects in mouse models of anxiety.

Technical Data for AZ 12216052

M. Wt 392.35
Formula C19H22BrNOS
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1290628-31-7
PubChem ID 73755190
Smiles BrC1=CC=C(CSCC(NC2=CC=C(C(C)CC)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for AZ 12216052

References are publications that support the biological activity of the product.

Chruscicka et al (2013) Expression of metabotropic glutamate receptors in mammalian cells as a method for identification of new chemical compounds with drug-like activity. Pharmacol.Rep. 65 38

Duvoisin et al (2011) Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges. Behav.Brain Res. 221 50 PMID: 21382421

Duvoisin et al (2010) Acute pharmacological modulation of mGluR8 reduces measures of anxiety. Behav.Brain Res. 212 168 PMID: 20385173

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Keywords: AZ 12216052, AZ 12216052 supplier, AZ12216052, anxiolytics, mGluR8, positive, allosteric, modulators, PAMs, Glutamate, (Metabotropic), Group, III, Receptors, 4832, Tocris Bioscience

Citations for AZ 12216052

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Currently there are no citations for AZ 12216052.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

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