AZ 12216052

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Cat.No. 4832 - AZ 12216052 | C19H22BrNOS | CAS No. 1290628-31-7
Description: Positive allosteric modulator at mGlu8
Chemical Name: 2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Positive allosteric modulator at mGlu8 receptors. Exhibits anxiolytic effects in mouse models of anxiety.

Technical Data

M. Wt 392.35
Formula C19H22BrNOS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1290628-31-7
PubChem ID 73755190
InChI Key QKUYZJOTWYRWNF-UHFFFAOYSA-N
Smiles BrC1=CC=C(CSCC(NC2=CC=C(C(C)CC)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.23 100
ethanol 39.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 392.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.49 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chruscicka et al (2013) Expression of metabotropic glutamate receptors in mammalian cells as a method for identification of new chemical compounds with drug-like activity. Pharmacol.Rep. 65 38 PMID:

Duvoisin et al (2011) Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges. Behav.Brain Res. 221 50 PMID: 21382421

Duvoisin et al (2010) Acute pharmacological modulation of mGluR8 reduces measures of anxiety. Behav.Brain Res. 212 168 PMID: 20385173


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Keywords: AZ12216052 anxiolytics mGluR8 positive allosteric modulators PAMs Glutamate (Metabotropic) Group III Receptors

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