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Cat.No. 1354 - Arvanil | C28H41NO3 | CAS No. 128007-31-8
Description: Potent CB1 and TRPV1 agonist. Also anandamide transport inhibitor
Chemical Name: N-[(4-Hydroxy-3-methoxyphenyl)methyl]-5Z,8Z,11Z,14Z-eicosatetraenamide
Purity: ≥98% (HPLC)

Biological Activity

Cannabinoid CB1 and vanilloid TRPV1 (VR1) agonist (Ki values are 0.5 and 0.3 μM respectively). Also inhibits the anandamide transporter (IC50 = 3.6 μM). Analgesic, vasodilatory and anti-inflammatory in vivo.

Technical Data

M. Wt 439.64
Formula C28H41NO3
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 128007-31-8
PubChem ID 6449767

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 439.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.37 mL 22.75 mL
5 mM 0.45 mL 2.27 mL 4.55 mL
10 mM 0.23 mL 1.14 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Di Marzo et al (2000) Neurobehavioral activity in mice of N-vanillyl-arachidonyl-amide. Eur.J.Pharmacol. 406 363 PMID: 11040343

Melck et al (1999) Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 receptors. Biochem.Biophys.Res.Commun. 262 275 PMID: 10448105

Szallasi and Di Marzo (2000) New perspectives on enigmatic vanilloid receptors. Trends Neurosci. 23 491 PMID: 11006466

If you know of a relevant reference for Arvanil, please let us know.

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Keywords: Arvanil, supplier, Potent, CB1, TRPV1, VR1, agonists, anandamide, transporters, inhibitors, inhibits, AMT, Cannabinoids, Monoamine, Neurotransmitter, Receptors, Vanillioid, TRPV, TRP, Channels, Transient, Receptor, Potential, cb1r, CB1, Receptors, TRPV, Cannabinoid, Transporters, CB1, Receptors, Tocris Bioscience

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