Highly potent and selective NOP receptor agonist (EC50 = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Longer lasting and 30-fold more potent than nociceptin in vivo; pronociceptive and inhibits locomotor activity.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1909.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.52 mL||2.62 mL||5.24 mL|
|5 mM||0.1 mL||0.52 mL||1.05 mL|
|10 mM||0.05 mL||0.26 mL||0.52 mL|
|50 mM||0.01 mL||0.05 mL||0.1 mL|
References are publications that support the products' biological activity.
Calo et al (2002) Pharmacological profile of nociceptin/orphanin FQ receptors. Clin.Exp.Pharmacol.Physiol. 29 223 PMID: 11906488
Okada et al (2000) Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem.Biophys.Res.Commun. 278 493 PMID: 11097863
Rizzi et al (2002) [Arg14,Lys15]Nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J.Pharmacol.Exp.Ther. 300 57 PMID: 11752097
If you know of a relevant reference for [Arg14,Lys15]Nociceptin, please let us know.
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Keywords: [Arg14,Lys15]-Nociceptin, supplier, potent, selective, NOP, agonists, Nociceptin, Receptors, ORL1, OP4, Opioid, NOP, Receptors, NOP, Receptors, Tocris Bioscience
1 Citation for [Arg14,Lys15]Nociceptin
Citations are publications that use Tocris products. Selected citations for [Arg14,Lys15]Nociceptin include:
Kuzmin et al (2004) Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol 141 132 PMID: 14662736
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.