Discontinued Product

[Arg14,Lys15]Nociceptin (Cat. No. 1590) has been withdrawn from sale for commercial reasons.
Description: Highly potent and selective NOP agonist
Citations (1)
Literature (1)

Biological Activity for [Arg14,Lys15]Nociceptin

[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor agonist (EC50 = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Longer lasting and 30-fold more potent than nociceptin in vivo; pronociceptive and inhibits locomotor activity.

Technical Data for [Arg14,Lys15]Nociceptin

M. Wt 1909.18
Formula C82H137N31O22
Storage Desiccate at -20°C
CAS Number 236098-40-1
PubChem ID 16143911
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for [Arg14,Lys15]Nociceptin

Certificate of Analysis / Product Datasheet
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References for [Arg14,Lys15]Nociceptin

References are publications that support the biological activity of the product.

Calo et al (2002) Pharmacological profile of nociceptin/orphanin FQ receptors. Clin.Exp.Pharmacol.Physiol. 29 223 PMID: 11906488

Okada et al (2000) Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem.Biophys.Res.Commun. 278 493 PMID: 11097863

Rizzi et al (2002) [Arg14,Lys15]Nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: in vitro and in vivo studies. J.Pharmacol.Exp.Ther. 300 57 PMID: 11752097

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Keywords: [Arg14,Lys15]-Nociceptin, [Arg14,Lys15]-Nociceptin supplier, potent, selective, NOP, agonists, Nociceptin, Receptors, ORL1, OP4, Opioid, 1590, Tocris Bioscience

1 Citation for [Arg14,Lys15]Nociceptin

Citations are publications that use Tocris products. Selected citations for [Arg14,Lys15]Nociceptin include:

Kuzmin et al (2004) Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. Br J Pharmacol 141 132 PMID: 14662736

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.