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Description: Selective Akt/PKB inhibitor. Antitumor
Chemical Name: 4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide
Purity: ≥96% (HPLC)
Biological Activity for API-1
API-1 is an Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growth arrest and apoptosis in human cancer cells expressing constitutively active Akt. Displays antitumor activity in vitro and in vivo.
Technical Data for API-1
| M. Wt | 337.29 |
| Formula | C13H15N5O6 |
| Storage | Store at RT |
| Purity | ≥96% (HPLC) |
| CAS Number | 36707-00-3 |
| PubChem ID | 24773090 |
| InChI Key | SPBWHPXCWJLQRU-FITJORAGSA-N |
| Smiles | O[C@@H]1[C@@H](CO)O[C@@H](N2C(N=CN=C3N)=C3C(C(C(N)=O)=C2)=O)[C@@H]1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for API-1
References for API-1
References are publications that support the biological activity of the product.
Saglam et al (2016) Effect of API-1 and FR180204 on cell proliferation and apoptosis in human DLD-1 and LoVo colorectal cancer cells. Oncol.Lett. 12 2463 PMID: 27698814
Ren et al (2013) The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis. Mol.Cancer 12 146 PMID: 24261825
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Keywords: API-1, API-1 supplier, protein, kinase, b, pkb, akt, inhibitors, inhibits, antitumor, antitumour, apoptosis, BAX, BAK, Mcl-1, colorectal, cancer, cells, Akt, (Protein, Kinase, B), Protein, B/Akt, Apoptosis, Inducers, 3897, Tocris Bioscience
4 Citations for API-1
Citations are publications that use Tocris products. Selected citations for API-1 include:
Arslan and Yerer (2018) α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167). Nutrients 10 PMID: 29799481
Jezierska-Drutel et al (2019) The peroxidase PRDX1 inhibits the activated phenotype in mammary fibroblasts through regulating c-Jun N-terminal kinases. BMC Cancer 19 812 PMID: 31419957
Shamblott et al (2016) Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2(TRKB) signaling in the adult human exocrine pancreas. Cell Communication and Signaling 14 23 PMID: 27659207
Zhu et al (2012) BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. EMBO J 31 31 PMID: 22463935
Reviews for API-1
Average Rating: 5 (Based on 1 Review.)
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Study of API-1 induction c-FLIP degradation and synergization with TRAIL to augment apoptosis.
By
Anonymous on 01/16/2020
Species: Human
Study of API-1 induction c-FLIP degradation and synergization with TRAIL to augment apoptosis.API-1 effectively induced apoptosis in tested cancer cell lines including activation of caspase-8 and caspase-9.
Pathways for API-1
