Pricing Availability   Qty
Description: Potent aromatase (CYP19) inhibitor
Alternative Names: ZD1033
Chemical Name: α1,α1,α3,α3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile
Purity: ≥99% (HPLC)

Biological Activity for Anastrozole

Anastrozole is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo. Orally active.

Licensing Information

Sold for research purposes only under agreement from AstraZeneca

Compound Libraries for Anastrozole

Anastrozole is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Anastrozole

M. Wt 293.37
Formula C17H19N5
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 120511-73-1
PubChem ID 2187
Smiles CC(C)(C#N)C1=CC(CN2C=NC=N2)=CC(C(C)(C)C#N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Anastrozole

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.34 100
ethanol 29.34 100

Preparing Stock Solutions for Anastrozole

The following data is based on the product molecular weight 293.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.41 mL 17.04 mL 34.09 mL
5 mM 0.68 mL 3.41 mL 6.82 mL
10 mM 0.34 mL 1.7 mL 3.41 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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References for Anastrozole

References are publications that support the biological activity of the product.

Dukes et al (1996) The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)-a potent, selective aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 58 439 PMID: 8903429

Goss and Tye (1997) Anastrozole: a new selective nonsteroidal aromatase inhibitor. Oncology 11 1697 PMID: 9394367

Buzda (2001) Anastrozole (ArimidexTM) - an aromatase inhibitor for the adjuvant setting? Br.J.Cancer 85 6 PMID: 11900212

If you know of a relevant reference for Anastrozole, please let us know.

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Citations for Anastrozole

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