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Potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo. Orally active.
Sold for research purposes only under agreement from AstraZeneca
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 293.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.41 mL||17.04 mL||34.09 mL|
|5 mM||0.68 mL||3.41 mL||6.82 mL|
|10 mM||0.34 mL||1.7 mL||3.41 mL|
|50 mM||0.07 mL||0.34 mL||0.68 mL|
References are publications that support the biological activity of the product.
Dukes et al (1996) The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)-a potent, selective aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 58 439 PMID: 8903429
Goss and Tye (1997) Anastrozole: a new selective nonsteroidal aromatase inhibitor. Oncology 11 1697 PMID: 9394367
Buzda (2001) Anastrozole (ArimidexTM) - an aromatase inhibitor for the adjuvant setting? Br.J.Cancer 85 6 PMID: 11900212
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Keywords: Anastrozole, Anastrozole supplier, Potent, aromatase, CYP19, inhibitors, inhibits, ERR, Estrogen, Receptors, Cytochrome, P450, AstraZeneca, ZD, 1033, ZD1033, and, Related, 3388, Tocris Bioscience
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