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Submit ReviewAnastrozole
Description: Potent aromatase (CYP19) inhibitor
Alternative Names: ZD1033
Chemical Name: α1,α1,α3,α3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile
Purity: ≥99% (HPLC)
Biological Activity for Anastrozole
Anastrozole is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo. Orally active.
Licensing Information
Sold for research purposes only under agreement from AstraZeneca
Compound Libraries for Anastrozole
Anastrozole is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Anastrozole
| M. Wt | 293.37 |
| Formula | C17H19N5 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 120511-73-1 |
| PubChem ID | 2187 |
| InChI Key | YBBLVLTVTVSKRW-UHFFFAOYSA-N |
| Smiles | CC(C)(C#N)C1=CC(CN2C=NC=N2)=CC(C(C)(C)C#N)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Anastrozole
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.34 | 100 | |
| ethanol | 29.34 | 100 |
Preparing Stock Solutions for Anastrozole
The following data is based on the product molecular weight 293.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.41 mL | 17.04 mL | 34.09 mL |
| 5 mM | 0.68 mL | 3.41 mL | 6.82 mL |
| 10 mM | 0.34 mL | 1.7 mL | 3.41 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
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Product Datasheets for Anastrozole
References for Anastrozole
References are publications that support the biological activity of the product.
Dukes et al (1996) The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)-a potent, selective aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 58 439 PMID: 8903429
Goss and Tye (1997) Anastrozole: a new selective nonsteroidal aromatase inhibitor. Oncology 11 1697 PMID: 9394367
Buzda (2001) Anastrozole (ArimidexTM) - an aromatase inhibitor for the adjuvant setting? Br.J.Cancer 85 6 PMID: 11900212
If you know of a relevant reference for Anastrozole, please let us know.
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Keywords: Anastrozole, Anastrozole supplier, Potent, aromatase, CYP19, inhibitors, inhibits, ERR, Estrogen, Receptors, Cytochrome, P450, AstraZeneca, ZD, 1033, ZD1033, and, Related, 3388, Tocris Bioscience
Citations for Anastrozole
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