Anastrozole

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Cat.No. 3388 - Anastrozole | C17H19N5 | CAS No. 120511-73-1
Description: Potent aromatase (CYP19) inhibitor
Alternative Names: ZD1033
Chemical Name: α1,α1,α3,α3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo. Orally active.

Licensing Information

Sold for research purposes only under agreement from AstraZeneca

Compound Libraries

Anastrozole is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 293.37
Formula C17H19N5
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 120511-73-1
PubChem ID 2187
InChI Key YBBLVLTVTVSKRW-UHFFFAOYSA-N
Smiles CC(C)(C#N)C1=CC(CN2C=NC=N2)=CC(C(C)(C)C#N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.34 100
ethanol 29.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 293.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.41 mL 17.04 mL 34.09 mL
5 mM 0.68 mL 3.41 mL 6.82 mL
10 mM 0.34 mL 1.7 mL 3.41 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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References

References are publications that support the biological activity of the product.

Dukes et al (1996) The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)-a potent, selective aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 58 439 PMID: 8903429

Goss and Tye (1997) Anastrozole: a new selective nonsteroidal aromatase inhibitor. Oncology 11 1697 PMID: 9394367

Buzda (2001) Anastrozole (ArimidexTM) - an aromatase inhibitor for the adjuvant setting? Br.J.Cancer 85 6 PMID: 11900212


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Citations for Anastrozole

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