Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAnastrozole is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo. Orally active.
Sold for research purposes only under agreement from AstraZeneca
Anastrozole is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
M. Wt | 293.37 |
Formula | C17H19N5 |
Storage | Store at RT |
Purity | ≥99% (HPLC) |
CAS Number | 120511-73-1 |
PubChem ID | 2187 |
InChI Key | YBBLVLTVTVSKRW-UHFFFAOYSA-N |
Smiles | CC(C)(C#N)C1=CC(CN2C=NC=N2)=CC(C(C)(C)C#N)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 29.34 | 100 | |
ethanol | 29.34 | 100 |
The following data is based on the product molecular weight 293.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.41 mL | 17.04 mL | 34.09 mL |
5 mM | 0.68 mL | 3.41 mL | 6.82 mL |
10 mM | 0.34 mL | 1.7 mL | 3.41 mL |
50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
References are publications that support the biological activity of the product.
Dukes et al (1996) The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)-a potent, selective aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 58 439 PMID: 8903429
Goss and Tye (1997) Anastrozole: a new selective nonsteroidal aromatase inhibitor. Oncology 11 1697 PMID: 9394367
Buzda (2001) Anastrozole (ArimidexTM) - an aromatase inhibitor for the adjuvant setting? Br.J.Cancer 85 6 PMID: 11900212
If you know of a relevant reference for Anastrozole, please let us know.
Keywords: Anastrozole, Anastrozole supplier, Potent, aromatase, CYP19, inhibitors, inhibits, ERR, Estrogen, Receptors, Cytochrome, P450, AstraZeneca, ZD, 1033, ZD1033, and, Related, 3388, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for Anastrozole. Do you know of a great paper that uses Anastrozole from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review Anastrozole and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image