Amitriptyline hydrochloride

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Cat.No. 4456 - Amitriptyline hydrochloride | C20H23N.HCl | CAS No. 549-18-8
Description: 5-HT and noradrenalin re-uptake inhibitor; also TrkA/B agonist
Chemical Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Inhibitor of serotonin and noradrenaline uptake; also activates α2A-adrenoceptors and antagonizes 5-HT2 receptors. Displays antinociceptive activity. Tricyclic antidepressant (TCA). Also a TrkA/B agonist. Induces neurite outgrowth in PC12 cells.

Technical Data

M. Wt 313.86
Formula C20H23N.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 549-18-8
PubChem ID 11065
InChI Key KFYRPLNVJVHZGT-UHFFFAOYSA-N
Smiles CN(CC\C=C2/C3=C(C=CC=C3)CCC1=CC=CC=C12)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 31.39 100
DMSO 31.39 100

Preparing Stock Solutions

The following data is based on the product molecular weight 313.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.19 mL 15.93 mL 31.86 mL
5 mM 0.64 mL 3.19 mL 6.37 mL
10 mM 0.32 mL 1.59 mL 3.19 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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References

References are publications that support the biological activity of the product.

Merck Index 12 85

Sanchez and Hyttel (1999) Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell.Mol.Neurobiol. 19 467 PMID: 10379421

Ghelardini et al (2000) Antinociception induced by amitriptyline and imipramine is mediated by α2A-adrenoceptors. Jpn.J.Pharmacol. 82 130 PMID: 10877531

Sawynok et al (2001) Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. J.Psychiatry Neurosci. 26 21 PMID: 11212590


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Citations for Amitriptyline hydrochloride

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Literature in this Area

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.