Amitriptyline hydrochloride

Pricing Availability   Qty

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Description: 5-HT and NA reuptake inhibitor (SNRI); also TrkA/B agonist
Chemical Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for Amitriptyline hydrochloride

Amitriptyline hydrochloride is an inhibitor of serotonin and noradrenaline uptake; also activates α2A-adrenoceptors and antagonizes 5-HT2 receptors. Displays antinociceptive activity. Tricyclic antidepressant (TCA). Also a TrkA/B agonist. Induces neurite outgrowth in PC12 cells.

Technical Data for Amitriptyline hydrochloride

M. Wt 313.86
Formula C20H23N.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 549-18-8
PubChem ID 11065
Smiles CN(CC\C=C2/C3=C(C=CC=C3)CCC1=CC=CC=C12)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Amitriptyline hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 31.39 100
DMSO 31.39 100

Preparing Stock Solutions for Amitriptyline hydrochloride

The following data is based on the product molecular weight 313.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.19 mL 15.93 mL 31.86 mL
5 mM 0.64 mL 3.19 mL 6.37 mL
10 mM 0.32 mL 1.59 mL 3.19 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets for Amitriptyline hydrochloride

References for Amitriptyline hydrochloride

References are publications that support the biological activity of the product.

Merck Index 12 85

Sanchez and Hyttel (1999) Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell.Mol.Neurobiol. 19 467 PMID: 10379421

Ghelardini et al (2000) Antinociception induced by amitript. and imipr. is mediated by α2A-adrenoceptors. Jpn.J.Pharmacol. 82 130 PMID: 10877531

Sawynok et al (2001) Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. J.Psychiatry Neurosci. 26 21 PMID: 11212590

If you know of a relevant reference for Amitriptyline hydrochloride, please let us know.

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Citations for Amitriptyline hydrochloride

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Literature in this Area

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