AM 12

Discontinued Product

AM 12 (Cat. No. 6495) has been withdrawn from sale for commercial reasons.
Description: TRPC5 inhibitor
Chemical Name: 2-(2-Bromophenyl)-3,5,7-trihydroxy-4H-chromen-4-one
Purity: ≥97% (HPLC)

Biological Activity for AM 12

AM 12 is a TRPC5 inhibitor (IC50 = 0.28 μM); Galangin (Cat. No. 6494) derivative. Exhibits some selectivity for TRPC5 over TRPC2, 3 and 4. Inhibits effects of TRPC5 activator (-)-Englerin A, but potentiates effects of physiological activators Sphingosine-1-phosphate (Cat. No.1370) and LPC.

Technical Data for AM 12

M. Wt 349.14
Formula C15H9BrO5
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 2387510-84-9
PubChem ID 137553166
Smiles OC1=CC(O)=C2C(OC(C3=C(Br)C=CC=C3)=C(C2=O)O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for AM 12

References are publications that support the biological activity of the product.

Naylor et al (2016) Natural and synthetic flavonoid modulation of TRPC5 channels. Br.J.Pharmacol. 173 562 PMID: 26565375

View Related Products by Target

View Related Products by Product Action

View all TRPC Channel Inhibitors

Keywords: AM 12, AM 12 supplier, AM12, canonical, transient, receptor, potential, channels, inhibitors, inhibits, TRPC5, TRPC, 6495, Tocris Bioscience

Citations for AM 12

Citations are publications that use Tocris products.

Currently there are no citations for AM 12.

Reviews for AM 12

There are currently no reviews for this product. Be the first to review AM 12 and earn rewards!

Have you used AM 12?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review