AM 12

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Cat.No. 6495 - AM 12 | C15H9BrO5
Description: TRPC5 inhibitor
Chemical Name: 2-(2-Bromophenyl)-3,5,7-trihydroxy-4H-chromen-4-one
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

TRPC5 inhibitor (IC50 = 0.28 μM); Galangin (Cat. No. 6494) derivative. Exhibits some selectivity for TRPC5 over TRPC2, 3 and 4. Inhibits effects of TRPC5 activator (-)-Englerin A, but potentiates effects of physiological activators Sphingosine-1-phosphate (Cat. No.1370) and LPC.

Technical Data

M. Wt 349.14
Formula C15H9BrO5
Storage Store at -20°C
Purity ≥97% (HPLC)
PubChem ID 137553166
InChI Key OVIAJBSVWWYJSD-UHFFFAOYSA-N
Smiles OC1=CC(O)=C2C(OC(C3=C(Br)C=CC=C3)=C(C2=O)O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.91 100
ethanol 17.46 50

Preparing Stock Solutions

The following data is based on the product molecular weight 349.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.86 mL 14.32 mL 28.64 mL
5 mM 0.57 mL 2.86 mL 5.73 mL
10 mM 0.29 mL 1.43 mL 2.86 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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References

References are publications that support the biological activity of the product.

Naylor et al (2016) Natural and synthetic flavonoid modulation of TRPC5 channels. Br.J.Pharmacol. 173 562 PMID: 26565375


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Keywords: AM 12, AM 12 supplier, AM12, canonical, transient, receptor, potential, channels, inhibitors, inhibits, TRPC5, TRPC, 6495, Tocris Bioscience

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