AM 12

Discontinued Product

AM 12 (Cat. No. 6495) has been withdrawn from sale for commercial reasons.
Description: TRPC5 inhibitor
Chemical Name: 2-(2-Bromophenyl)-3,5,7-trihydroxy-4H-chromen-4-one
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for AM 12

AM 12 is a TRPC5 inhibitor (IC50 = 0.28 μM); Galangin (Cat. No. 6494) derivative. Exhibits some selectivity for TRPC5 over TRPC2, 3 and 4. Inhibits effects of TRPC5 activator (-)-Englerin A, but potentiates effects of physiological activators Sphingosine-1-phosphate (Cat. No.1370) and LPC.

Technical Data for AM 12

M. Wt 349.14
Formula C15H9BrO5
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 2387510-84-9
PubChem ID 137553166
InChI Key OVIAJBSVWWYJSD-UHFFFAOYSA-N
Smiles OC1=CC(O)=C2C(OC(C3=C(Br)C=CC=C3)=C(C2=O)O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for AM 12

References are publications that support the biological activity of the product.

Naylor et al (2016) Natural and synthetic flavonoid modulation of TRPC5 channels. Br.J.Pharmacol. 173 562 PMID: 26565375

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Keywords: AM 12, AM 12 supplier, AM12, canonical, transient, receptor, potential, channels, inhibitors, inhibits, TRPC5, TRPC, 6495, Tocris Bioscience

Citations for AM 12

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