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AM 12

Cat. No. 6495 Submit a Review Datasheet / COA / SDS
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Description: TRPC5 inhibitor
Chemical Name: 2-(2-Bromophenyl)-3,5,7-trihydroxy-4H-chromen-4-one
Purity: ≥97% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AM 12

AM 12 is a TRPC5 inhibitor (IC50 = 0.28 μM); Galangin (Cat. No. 6494) derivative. Exhibits some selectivity for TRPC5 over TRPC2, 3 and 4. Inhibits effects of TRPC5 activator (-)-Englerin A, but potentiates effects of physiological activators Sphingosine-1-phosphate (Cat. No.1370) and LPC.

Technical Data for AM 12

M. Wt 349.14
Formula C15H9BrO5
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 2387510-84-9
PubChem ID 137553166
InChI Key OVIAJBSVWWYJSD-UHFFFAOYSA-N
Smiles OC1=CC(O)=C2C(OC(C3=C(Br)C=CC=C3)=C(C2=O)O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AM 12

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.91 100
ethanol 17.46 50

Preparing Stock Solutions for AM 12

The following data is based on the product molecular weight 349.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.86 mL 14.32 mL 28.64 mL
5 mM 0.57 mL 2.86 mL 5.73 mL
10 mM 0.29 mL 1.43 mL 2.86 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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References for AM 12

References are publications that support the biological activity of the product.

Naylor et al (2016) Natural and synthetic flavonoid modulation of TRPC5 channels. Br.J.Pharmacol. 173 562 PMID: 26565375

If you know of a relevant reference for AM 12, please let us know.

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Citations for AM 12

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