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Galangin

Cat. No. 6494 Submit a Review Datasheet / COA / SDS
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Cat.No. 6494 - Galangin | C15H10O5 | CAS No. 548-83-4
Description: TRPC5 inhibitor; also induces autophagy
Chemical Name: 3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

TRPC5 inhibitor. Inhibits Ca2+ entry into TRPC5 expressing cells. Inhibits LPS-induced expression of TNFα, IL-6, IL-1β, COX2 and iNOS, in vitro. Attenuates microglial activation, loss of dopaminergic neurons and motor dysfunction in a LPS-induced rat model of Parkinson's disease. Also inhibits proliferation in breast cancer cell lines. Induces autophagy. Also displays antiviral activity against HSV-1, coxsackie B virus type 1, adenovirus type 31 and reovirus.

Technical Data

M. Wt 270.24
Formula C15H10O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 548-83-4
PubChem ID 5281616
InChI Key VCCRNZQBSJXYJD-UHFFFAOYSA-N
Smiles OC1=CC(O)=C2C(OC(C3=CC=CC=C3)=C(C2=O)O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.02 100
ethanol 13.51 50

Preparing Stock Solutions

The following data is based on the product molecular weight 270.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.7 mL 18.5 mL 37 mL
5 mM 0.74 mL 3.7 mL 7.4 mL
10 mM 0.37 mL 1.85 mL 3.7 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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References

References are publications that support the biological activity of the product.

Naylor et al (2016) Natural and synthetic flavonoid modulation of TRPC5 channels. Br.J.Pharmacol. 173 562 PMID: 26565375

Chen et al (2017) Galangin reduces the loss of DArgic neurons in an LPS-evoked model of Parkinson's disease in rats. Int.J.Mol.Sci. 19 PMID: 29267220

So et al (1996) Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr.Cancer. 26 167 PMID: 8875554

Wen et al (2012) Galangin induces autophagy through upregulation of p53 in HepG2 cells. Pharmacology. 89 247 PMID: 22507894

Meyer et al (1997) Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens. J.Ethnopharmacol. 56 165 PMID: 9174978

If you know of a relevant reference for Galangin, please let us know.

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Keywords: Galangin, Galangin supplier, Galangin, TRPC5, inhibitors, autophagy, inducers, flavonoids, inhibits, induces, Autophagy, TRPC, Non-selective, Antivirals, 6494, Tocris Bioscience

Citations for Galangin

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