Altanserin hydrochloride

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Cat.No. 1809 - Altanserin hydrochloride | C22H22FN3O2S.HCl | CAS No. 1135280-78-2
Description: 5-HT2A receptor antagonist
Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Potent and selective 5-HT2A receptor antagonist (Ki values are 0.13, 4.55, 40, 62 and 1570 nM at 5-HT2A, α1, 5-HT2C, D2 and 5-HT1A respectively). Centrally active following systemic administration in vivo.

Compound Libraries

Altanserin hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 447.95
Formula C22H22FN3O2S.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 1135280-78-2
PubChem ID 24978536
InChI Key JFPPLMAMMZZOEA-UHFFFAOYSA-N
Smiles Cl.FC1=CC=C(C=C1)C(=O)C1CCN(CCN2C(=S)NC3=CC=CC=C3C2=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.96 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 447.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.16 mL 22.32 mL
5 mM 0.45 mL 2.23 mL 4.46 mL
10 mM 0.22 mL 1.12 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Herth et al (2009) Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET. Bioorg.Med.Chem. 17 2989 PMID: 19329329

Kennett et al (1994) Evidence that 5-HT2C receptor antagonists are anxiolytic in the rat Geller-Seifter model of anxiety. Psychopharmacology 114 90 PMID: 7846211

Koenig et al (1987) Stimulation of corticosterone and β-endorphin secretion in the rat by selective 5-HT receptor subtype activation. Eur.J.Pharmacol. 137 1 PMID: 2956114

Sietnick (1985) Involvement of 5-HT2 receptors in the LSD- and L-5-HTP-induced suppression of lordotic behavior in the female rat. J.Neural Transm. 61 65 PMID: 3872342


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Keywords: Altanserin hydrochloride, supplier, 5-HT2A, receptor, antagonists, Serotonin, Receptors, 5-HT2A, Receptors, 5-HT2A, Receptors, Tocris Bioscience

2 Citations for Altanserin hydrochloride

Citations are publications that use Tocris products. Selected citations for Altanserin hydrochloride include:

Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. Am J Physiol Regul Integr Comp Physiol 6 e21395 PMID: 21789169

Yu and Yamaguchi (2009) 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations. J Neurophysiol 102 752 PMID: 19474172


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