Discontinued Product

Alphaxalone (Cat. No. 3046) has been withdrawn from sale for commercial reasons.
Description: Direct activator and potentiator of GABAA
Chemical Name: (3α,5α)-3-Hydroxypregnane-11,20-dione
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Alphaxalone

A neurosteroid anesthetic that directly activates and potentiates GABAA receptor-activated membrane current (IGABA). Efficacy but not potency is determined by the alpha subunit of the receptor (EC50 values are 1.4, 1.8, 2.1, 2.4 and 2.5 μM for α1β1γ3, α1β1γ1, β1γ1, α2β1γ2L and α1β1γ2L isoforms respectively).

Technical Data for Alphaxalone

M. Wt 332.48
Formula C21H32O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 23930-19-0
PubChem ID 104845
Smiles O=[C@](C)[C@H]3CC[C@@]([C@@](C)3C4)([H])[C@]2([H])CC[C@@]1([H])C[C@H](O)CC[C@@](C)1[C@]([H])2C4=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Alphaxalone

Certificate of Analysis / Product Datasheet
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References for Alphaxalone

References are publications that support the biological activity of the product.

Maitra et al (1999) Subunit dependent modulation of GABAA receptor function by neuroactive steroids. Brain Res. 819 75 PMID: 10082863

Wegner et al (2007) Auto-modulation of neuroactive steroids on GABAA receptors: a novel pharmacological effect. Neuropharmacology. 52 672 PMID: 17084864

Zecharia et al (2009) The involvement of hypothalamic sleep pathways in general anesthesia: Testing the hypothesis using the GABAA receptor β3N265M knock-in mouse. J.Neurosci. 29 2177 PMID: 19228970

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Keywords: Alphaxalone, Alphaxalone supplier, Direct, activators, potentiator, GABAA, Receptors, 3046, Tocris Bioscience

Citations for Alphaxalone

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Currently there are no citations for Alphaxalone.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.