Pricing Availability Delivery Time Qty
Cat.No. 3046 - Alphaxalone | C21H32O3 | CAS No. 23930-19-0
Description: Direct activator and potentiator of GABAA
Chemical Name: (3α,5α)-3-Hydroxypregnane-11,20-dione
Purity: ≥98% (HPLC)

Biological Activity

A neurosteroid anesthetic that directly activates and potentiates GABAA receptor-activated membrane current (IGABA). Efficacy but not potency is determined by the alpha subunit of the receptor (EC50 values are 1.4, 1.8, 2.1, 2.4 and 2.5 μM for α1β1γ3, α1β1γ1, β1γ1, α2β1γ2L and α1β1γ2L isoforms respectively).

Technical Data

M. Wt 332.48
Formula C21H32O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 23930-19-0
PubChem ID 104845
Smiles O=[C@](C)[C@H]3CC[C@@]([C@@](C)3C4)([H])[C@]2([H])CC[C@@]1([H])C[C@H](O)CC[C@@](C)1[C@]([H])2C4=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.25 100
ethanol 33.25 100

Preparing Stock Solutions

The following data is based on the product molecular weight 332.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.04 mL 30.08 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
10 mM 0.3 mL 1.5 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Maitra et al (1999) Subunit dependent modulation of GABAA receptor function by neuroactive steroids. Brain Res. 819 75 PMID: 10082863

Wegner et al (2007) Auto-modulation of neuroactive steroids on GABAA receptors: a novel pharmacological effect. Neuropharmacology. 52 672 PMID: 17084864

Zecharia et al (2009) The involvement of hypothalamic sleep pathways in general anesthesia: Testing the hypothesis using the GABAA receptor β3N265M knock-in mouse. J.Neurosci. 29 2177 PMID: 19228970

If you know of a relevant reference for Alphaxalone, please let us know.

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Keywords: Alphaxalone, supplier, Direct, activators, potentiator, GABAA, Receptors, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience

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