Allopregnanolone

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Cat.No. 3653 - Allopregnanolone | C21H34O2 | CAS No. 516-54-1
Description: Positive allosteric modulator of GABAA receptors
Alternative Names: 3a,5a-THPROG
Chemical Name: (3α,5α)-3-Hydroxy-pregnan-20-one
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

GABAA receptor positive allosteric modulator. Neuroactive steroid.

Deuterated analog also available.

Compound Libraries

Allopregnanolone is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 318.49
Formula C21H34O2
Storage Store at RT
CAS Number 516-54-1
PubChem ID 92786
InChI Key AURFZBICLPNKBZ-SYBPFIFISA-N
Smiles C[C@@]12[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(C)=O)([H])C[C@H](O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.85 100
ethanol 31.85 100

Preparing Stock Solutions

The following data is based on the product molecular weight 318.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.14 mL 15.7 mL 31.4 mL
5 mM 0.63 mL 3.14 mL 6.28 mL
10 mM 0.31 mL 1.57 mL 3.14 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Puia et al (1990) Neurosteroids act on recombinant human GABAA receptors. Neuron 4 759 PMID: 2160838

Belelli and Lambert (2005) Neurosteroids: endogenous regulators of the GABAA receptor. Nat.Rev.Neurosci. 6 565 PMID: 15959466

Agis-Balboa et al (2006) Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc.Natl.Acad.Sci.USA 103 14602


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Keywords: Allopregnanolone, Allopregnanolone supplier, GABAA, receptors, positive, allosteric, modulators, neuroactive, steroid, 3a,5a-THPROG, Receptors, 3653, Tocris Bioscience

2 Citations for Allopregnanolone

Citations are publications that use Tocris products. Selected citations for Allopregnanolone include:

Ferando and Mody (2013) Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits 7 144 PMID: 24062647

Earl (2011) Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors. J Pharmacol Exp Ther 337 301 PMID: 21262851


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

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