Allopregnanolone

Pricing Availability   Qty
Description: Positive allosteric modulator of GABAA receptors
Alternative Names: 3a,5a-THPROG
Chemical Name: (3α,5α)-3-Hydroxy-pregnan-20-one
Datasheet
Citations (4)
Reviews
Literature (2)

Biological Activity for Allopregnanolone

Allopregnanolone is a GABAA receptor positive allosteric modulator. Neuroactive steroid.

Technical Data for Allopregnanolone

M. Wt 318.49
Formula C21H34O2
Storage Store at RT
CAS Number 516-54-1
PubChem ID 92786
InChI Key AURFZBICLPNKBZ-SYBPFIFISA-N
Smiles C[C@@]12[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(C)=O)([H])C[C@H](O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Allopregnanolone

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.85 100
ethanol 31.85 100

Preparing Stock Solutions for Allopregnanolone

The following data is based on the product molecular weight 318.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.14 mL 15.7 mL 31.4 mL
5 mM 0.63 mL 3.14 mL 6.28 mL
10 mM 0.31 mL 1.57 mL 3.14 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets for Allopregnanolone

Certificate of Analysis / Product Datasheet
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References for Allopregnanolone

References are publications that support the biological activity of the product.

Puia et al (1990) Neurosteroids act on recombinant human GABAA receptors. Neuron 4 759 PMID: 2160838

Belelli and Lambert (2005) Neurosteroids: endogenous regulators of the GABAA receptor. Nat.Rev.Neurosci. 6 565 PMID: 15959466

Agis-Balboa et al (2006) Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc.Natl.Acad.Sci.USA 103 14602


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Keywords: Allopregnanolone, Allopregnanolone supplier, GABAA, receptors, positive, allosteric, modulators, neuroactive, steroid, PAM, 3a,5a-THPROG, Receptors, 3653, Tocris Bioscience

4 Citations for Allopregnanolone

Citations are publications that use Tocris products. Selected citations for Allopregnanolone include:

Michael et al (2021) Placental endocrine function shapes cerebellar development and social behavior. Nat Neurosci 24 1392-1401 PMID: 34400844

Scott M et al (2020) Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain. Neuropsychopharmacology 45 1263 PMID: 32045935

Earl (2011) Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors. J Pharmacol Exp Ther 337 301 PMID: 21262851

Ferando and Mody (2013) Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits 7 144 PMID: 24062647


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Reviews for Allopregnanolone

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.