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Allopregnanolone is a GABAA receptor positive allosteric modulator. Neuroactive steroid.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 318.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.14 mL||15.7 mL||31.4 mL|
|5 mM||0.63 mL||3.14 mL||6.28 mL|
|10 mM||0.31 mL||1.57 mL||3.14 mL|
|50 mM||0.06 mL||0.31 mL||0.63 mL|
References are publications that support the biological activity of the product.
Puia et al (1990) Neurosteroids act on recombinant human GABAA receptors. Neuron 4 759 PMID: 2160838
Belelli and Lambert (2005) Neurosteroids: endogenous regulators of the GABAA receptor. Nat.Rev.Neurosci. 6 565 PMID: 15959466
Agis-Balboa et al (2006) Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc.Natl.Acad.Sci.USA 103 14602
If you know of a relevant reference for Allopregnanolone, please let us know.
Keywords: Allopregnanolone, Allopregnanolone supplier, GABAA, receptors, positive, allosteric, modulators, neuroactive, steroid, PAM, 3a,5a-THPROG, Receptors, 3653, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Allopregnanolone include:
Earl (2011) Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors. J Pharmacol Exp Ther 337 301 PMID: 21262851
Ferando and Mody (2013) Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits 7 144 PMID: 24062647
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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