Alexidine dihydrochloride

Pricing Availability   Qty
Cat.No. 3979 - Alexidine dihydrochloride | C26H56N10.2HCl | CAS No. 1715-30-6
Description: Selective inhibitor of PTPMT1
Chemical Name: N,N''-Bis(2-ethylhexyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide dihydrochloride
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC50 = 1.08 μM in vitro). Stimulates increased insulin secretion by β-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells. Also preserves functional hematopoietic stem cells ex vivo.

Technical Data

M. Wt 581.71
Formula C26H56N10.2HCl
Storage Desiccate at -20°C
CAS Number 1715-30-6
PubChem ID 102678
InChI Key BRJJFBHTDVWTCJ-UHFFFAOYSA-N
Smiles N=C(NC(NCC(CC)CCCC)=N)NCCCCCCNC(NC(NCC(CC)CCCC)=N)=N.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 58.17 100
ethanol 58.17 100

Preparing Stock Solutions

The following data is based on the product molecular weight 581.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.72 mL 8.6 mL 17.19 mL
5 mM 0.34 mL 1.72 mL 3.44 mL
10 mM 0.17 mL 0.86 mL 1.72 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Yip et al (2006) Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Mol.Cancer Ther. 5 2234 PMID: 16985057

Doughty-Shenton et al (2010) Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J.Pharmacol.Exp.Ther. 333 584 PMID: 20167843

Liu et al (2015) Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism. Blood 125 1562 PMID: 25593337


If you know of a relevant reference for Alexidine dihydrochloride, please let us know.

View Related Products by Product Action

View all Protein Tyrosine Phosphatases Inhibitors

Keywords: Alexidine dihydrochloride, Alexidine dihydrochloride supplier, protein, tyrosine, phosphatases, PTP, localized, localised, to, mitochondrion, 1, PTPMT1, inhibitors, inhibits, stem, cells, Protein, Tyrosine, Phosphatases, Stem, Cell, Signaling, 3979, Tocris Bioscience

1 Citation for Alexidine dihydrochloride

Citations are publications that use Tocris products. Selected citations for Alexidine dihydrochloride include:

Niemi et al (2013) Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death. PLoS One 8 e53803 PMID: 23326511


Do you know of a great paper that uses Alexidine dihydrochloride from Tocris? Please let us know.

Reviews for Alexidine dihydrochloride

There are currently no reviews for this product. Be the first to review Alexidine dihydrochloride and earn rewards!

Have you used Alexidine dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis