Selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC50 = 1.08 μM in vitro). Stimulates increased insulin secretion by β-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells. Also preserves functional hematopoietic stem cells ex vivo.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 581.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.72 mL||8.6 mL||17.19 mL|
|5 mM||0.34 mL||1.72 mL||3.44 mL|
|10 mM||0.17 mL||0.86 mL||1.72 mL|
|50 mM||0.03 mL||0.17 mL||0.34 mL|
References are publications that support the biological activity of the product.
Yip et al (2006) Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Mol.Cancer Ther. 5 2234 PMID: 16985057
Doughty-Shenton et al (2010) Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J.Pharmacol.Exp.Ther. 333 584 PMID: 20167843
Liu et al (2015) Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism. Blood 125 1562 PMID: 25593337
If you know of a relevant reference for Alexidine dihydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Alexidine dihydrochloride, Alexidine dihydrochloride supplier, protein, tyrosine, phosphatases, PTP, localized, localised, to, mitochondrion, 1, PTPMT1, inhibitors, inhibits, stem, cells, Protein, Tyrosine, Phosphatases, Stem, Cell, Signaling, 3979, Tocris Bioscience
1 Citation for Alexidine dihydrochloride
Citations are publications that use Tocris products. Selected citations for Alexidine dihydrochloride include:
Niemi et al (2013) Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death. PLoS One 8 e53803 PMID: 23326511
Do you know of a great paper that uses Alexidine dihydrochloride from Tocris? Please let us know.
Reviews for Alexidine dihydrochloride
There are currently no reviews for this product. Be the first to review Alexidine dihydrochloride and earn rewards!
Have you used Alexidine dihydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.