AL 8697

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Potent and selective p38α inhibitor
Chemical Name: N-Cyclopropyl-3-[3-(1,1-dimethylethyl)-6,8-difluoro-1,2,4-triazolo[4,3-a]pyridin-7-yl]-5-fluoro-4-methylbenzamide
Purity: ≥98% (HPLC)
Literature (1)
Pathways (1)

Biological Activity for AL 8697

AL 8697 is a potent and selective p38α inhibitor (IC50 = 6 nM). Exhibits 14-fold greater inhibition of p38α compared to p38β; also displays 300-fold selectivity for p38α compared to a panel of 91 kinases. Exhibits anti-inflammatory properties.

Compound Libraries for AL 8697

AL 8697 is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AL 8697

M. Wt 402.41
Formula C21H21F3N4O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1057394-06-5
PubChem ID 25060093
Smiles CC1=C(F)C=C(C(NC4CC4)=O)C=C1C3=C(F)C2=NN=C(C(C)(C)C)N2C=C3F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AL 8697

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 40.24 100
ethanol 20.12 50

Preparing Stock Solutions for AL 8697

The following data is based on the product molecular weight 402.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.43 mL 24.85 mL
5 mM 0.5 mL 2.49 mL 4.97 mL
10 mM 0.25 mL 1.24 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for AL 8697

Certificate of Analysis / Product Datasheet
Select another batch:

References for AL 8697

References are publications that support the biological activity of the product.

Balagué et al (2012) Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study. Br.J.Pharmacol. 166 1320 PMID: 22229697

Aiguadé et al (2012) Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. Bioorg.Med.Chem.Lett. 22 3431 PMID: 22521646

If you know of a relevant reference for AL 8697, please let us know.

View Related Products by Target

View Related Products by Product Action

View all p38 MAPK Inhibitors

Keywords: AL 8697, AL 8697 supplier, AL8697, potent, selective, p38, alpha, inhibitors, inhibits, anti-inflammatory, 4753, Tocris Bioscience

Citations for AL 8697

Citations are publications that use Tocris products.

Currently there are no citations for AL 8697. Do you know of a great paper that uses AL 8697 from Tocris? Please let us know.

Reviews for AL 8697

There are currently no reviews for this product. Be the first to review AL 8697 and earn rewards!

Have you used AL 8697?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for AL 8697

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.