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AL 8697

Cat. No. 4753 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective p38α inhibitor
Chemical Name: N-Cyclopropyl-3-[3-(1,1-dimethylethyl)-6,8-difluoro-1,2,4-triazolo[4,3-a]pyridin-7-yl]-5-fluoro-4-methylbenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for AL 8697

AL 8697 is a potent and selective p38α inhibitor (IC50 = 6 nM). Exhibits 14-fold greater inhibition of p38α compared to p38β; also displays 300-fold selectivity for p38α compared to a panel of 91 kinases. Exhibits anti-inflammatory properties.

Compound Libraries for AL 8697

AL 8697 is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AL 8697

M. Wt 402.41
Formula C21H21F3N4O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1057394-06-5
PubChem ID 25060093
InChI Key ZVBTZTQYHOXIBC-UHFFFAOYSA-N
Smiles CC1=C(F)C=C(C(NC4CC4)=O)C=C1C3=C(F)C2=NN=C(C(C)(C)C)N2C=C3F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AL 8697

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.24 100
ethanol 20.12 50

Preparing Stock Solutions for AL 8697

The following data is based on the product molecular weight 402.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.43 mL 24.85 mL
5 mM 0.5 mL 2.49 mL 4.97 mL
10 mM 0.25 mL 1.24 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets for AL 8697

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for AL 8697

References are publications that support the biological activity of the product.

Balagué et al (2012) Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study. Br.J.Pharmacol. 166 1320 PMID: 22229697

Aiguadé et al (2012) Novel triazolopyridylbenzamides as potent and selective p38α inhibitors. Bioorg.Med.Chem.Lett. 22 3431 PMID: 22521646

If you know of a relevant reference for AL 8697, please let us know.

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Keywords: AL 8697, AL 8697 supplier, AL8697, potent, selective, p38, alpha, inhibitors, inhibits, anti-inflammatory, 4753, Tocris Bioscience

Citations for AL 8697

Citations are publications that use Tocris products.

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Reviews for AL 8697

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Literature in this Area

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Pathways for AL 8697

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.