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Inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC50 = 20 μM).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 280.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.57 mL||17.84 mL||35.67 mL|
|5 mM||0.71 mL||3.57 mL||7.13 mL|
|10 mM||0.36 mL||1.78 mL||3.57 mL|
|50 mM||0.07 mL||0.36 mL||0.71 mL|
References are publications that support the biological activity of the product.
Gallo (2006) Targeting HSP90 to halt neurodegeneration. Chem.Biol. 13 115 PMID: 16492558
Salehi et al (2006) AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem.Biol. 13 213 PMID: 16492569
If you know of a relevant reference for AEG 3482, please let us know.
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Keywords: AEG 3482, AEG 3482 supplier, inhibitors, inhibits, JNK, signaling, Mitogen-Activated, Protein, Kinases, c-Jun, N-Terminal, SAPKs, Stress-Activated, AEG3482, JNK/c-jun, 2651, Tocris Bioscience
5 Citations for AEG 3482
Citations are publications that use Tocris products. Selected citations for AEG 3482 include:
Lahiri et al (2016) ERK2 phosphorylates Krüppel-like factor 8 protein at serine 48 to maintain its stability. Am J Cancer Res 6 910 PMID: 27293988
Xiao et al (2019) Targeting JNK pathway promotes human hematopoietic stem cell expansion. Cell Discov 5 2 PMID: 30622738
Ryals et al (2018) The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity. Front Cell Neurosci 12 445 PMID: 30532693
Baston-Buest et al (2017) Syndecan-1 Acts as an Important Regulator of CXCL1 Expression and Cellular Interaction of Human Endometrial Stromal and Trophoblast Cells. Mediators Inflamm 2017 8379256 PMID: 28293067
Roselli et al (2011) CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton. PLoS One 6 e23097 PMID: 21829588
Do you know of a great paper that uses AEG 3482 from Tocris? Please let us know.
Reviews for AEG 3482
Average Rating: 3 (Based on 1 Review.)
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Zebrafish larvae were placed into 48-well plates and used the DASPEI screen by 42 perturbagens drugs, including this compound
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.