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Description: Inhibits viral DNA polymerase; antiherpetic agent
Alternative Names: Aciclovir,Acycloguanosine
Chemical Name: 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
Purity: ≥99% (HPLC)
Reviews (1)
Literature (1)

Biological Activity for Acyclovir

Acyclovir is an antiviral agent, active against herpes simplex viruses HSV-1 and HSV-2 (EC50 values are 0.85 and 0.86 μM respectively). Interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate. Induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy).

Compound Libraries for Acyclovir

Acyclovir is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Acyclovir

M. Wt 225.21
Formula C8H11N5O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 59277-89-3
PubChem ID 2022
Smiles NC1=NC(=O)C2=C(N1)N(COCCO)C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Acyclovir

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 11.26 50
DMSO 4.5 20

Preparing Stock Solutions for Acyclovir

The following data is based on the product molecular weight 225.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.88 mL 44.4 mL 88.81 mL
2.5 mM 1.78 mL 8.88 mL 17.76 mL
5 mM 0.89 mL 4.44 mL 8.88 mL
25 mM 0.18 mL 0.89 mL 1.78 mL

Molarity Calculator

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Product Datasheets for Acyclovir

Certificate of Analysis / Product Datasheet
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References for Acyclovir

References are publications that support the biological activity of the product.

Hayashi et al (2006) The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy. J.Gene.Med. 8 1056 PMID: 16779868

Suzuki et al (2006) Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 72 157 PMID: 16797734

Elion et al (1977) Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine. Proc.Natl.Acad.Sci.USA. 74 5716

If you know of a relevant reference for Acyclovir, please let us know.

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Keywords: Acyclovir, Acyclovir supplier, Viral, DNA, polymerases, inhibitors, inhibits, antiherpetic, agent, Synthesis, antiviral, Aciclovir, Acycloguanosine, Polymerase, DNA,, RNA, and, Protein, Herpes, Simplex, Viruses, 2513, Tocris Bioscience

Citations for Acyclovir

Citations are publications that use Tocris products.

Currently there are no citations for Acyclovir. Do you know of a great paper that uses Acyclovir from Tocris? Please let us know.

Reviews for Acyclovir

Average Rating: 4 (Based on 1 Review.)

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Acyclovir was studied in conjunction with few contemporary chemotherapy strategies.
By Anonymous on 08/18/2019
Species: Human

Acyclovir's effect was seen to increased when used with certain other medicines namely chemotherapeutic. Acyclovir was studied in conjunction with few contemporary chemotherapy strategies.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.