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Antiviral agent, active against herpes simplex viruses HSV-1 and HSV-2 (EC50 values are 0.85 and 0.86 μM respectively). Interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate. Induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 225.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||8.88 mL||44.4 mL||88.81 mL|
|2.5 mM||1.78 mL||8.88 mL||17.76 mL|
|5 mM||0.89 mL||4.44 mL||8.88 mL|
|25 mM||0.18 mL||0.89 mL||1.78 mL|
References are publications that support the biological activity of the product.
Hayashi et al (2006) The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy. J.Gene.Med. 8 1056 PMID: 16779868
Suzuki et al (2006) Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 72 157 PMID: 16797734
Elion et al (1977) Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine. Proc.Natl.Acad.Sci.USA. 74 5716
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Keywords: Acyclovir, Acyclovir supplier, Viral, DNA, polymerases, inhibitors, inhibits, antiherpetic, agent, Synthesis, antiviral, Aciclovir, Acycloguanosine, Polymerase, DNA,, RNA, and, Protein, Herpes, Simplex, Viruses, 2513, Tocris Bioscience
Citations for Acyclovir
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Reviews for Acyclovir
Average Rating: 4 (Based on 1 Review.)
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Acyclovir's effect was seen to increased when used with certain other medicines namely chemotherapeutic. Acyclovir was studied in conjunction with few contemporary chemotherapy strategies.
Literature in this Area
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Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.