Antiviral agent, active against herpes simplex viruses HSV-1 and HSV-2 (EC50 values are 0.85 and 0.86 μM respectively). Interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate. Induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 225.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.44 mL||22.2 mL||44.4 mL|
|5 mM||0.89 mL||4.44 mL||8.88 mL|
|10 mM||0.44 mL||2.22 mL||4.44 mL|
|50 mM||0.09 mL||0.44 mL||0.89 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Hayashi et al (2006) The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy. J.Gene.Med. 8 1056 PMID: 16779868
Suzuki et al (2006) Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 72 157 PMID: 16797734
If you know of a relevant reference for Acyclovir, please let us know.
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Keywords: Acyclovir, supplier, Viral, DNA, polymerases, inhibitors, inhibits, antiherpetic, agent, Synthesis, antiviral, Aciclovir, Acycloguanosine, RNA/DNA, Polymerase, Tocris Bioscience
Citations for Acyclovir
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Literature in this Area
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.