Acyclovir

Pricing Availability Delivery Time Qty
Cat.No. 2513 - Acyclovir | C8H11N5O3 | CAS No. 59277-89-3
Description: Inhibits viral DNA polymerase; antiherpetic agent
Alternative Names: Aciclovir, Acycloguanosine
Chemical Name: 2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Antiviral agent, active against herpes simplex viruses HSV-1 and HSV-2 (EC50 values are 0.85 and 0.86 μM respectively). Interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate. Induces apoptosis in cells transfected with HSV-TK (suicidal gene therapy).

Compound Libraries

Acyclovir is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 225.21
Formula C8H11N5O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 59277-89-3
PubChem ID 2022
InChI Key MKUXAQIIEYXACX-UHFFFAOYSA-N
Smiles NC1=NC(=O)C2=C(N1)N(COCCO)C=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 11.26 50
DMSO 4.5 20

Preparing Stock Solutions

The following data is based on the product molecular weight 225.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.44 mL 22.2 mL 44.4 mL
5 mM 0.89 mL 4.44 mL 8.88 mL
10 mM 0.44 mL 2.22 mL 4.44 mL
50 mM 0.09 mL 0.44 mL 0.89 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Hayashi et al (2006) The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy. J.Gene.Med. 8 1056 PMID: 16779868

Suzuki et al (2006) Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 72 157 PMID: 16797734

Elion et al (1977) Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine. Proc.Natl.Acad.Sci.USA. 74 5716 PMID:


If you know of a relevant reference for Acyclovir, please let us know.

View Related Products by Product Action

View all RNA/DNA Polymerase Inhibitors

Keywords: Acyclovir, supplier, Viral, DNA, polymerases, inhibitors, inhibits, antiherpetic, agent, Synthesis, antiviral, Aciclovir, Acycloguanosine, RNA/DNA, Polymerase, DNA,, RNA, and, Protein, Synthesis, Antivirals, RNA/DNA, Polymerase, Tocris Bioscience

Citations for Acyclovir

Citations are publications that use Tocris products.

Currently there are no citations for Acyclovir. Do you know of a great paper that uses Acyclovir from Tocris? If so please let us know.

Acyclovir Reviews

Average Rating:

(Based on 0 Reviews)


1 Star
0%
2 Star
0%
3 Star
0%
4 Star
0%
5 Star
0%

Have you used Acyclovir?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.


Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.