Ac-RYYRWK-NH2

Pricing Availability Delivery Time Qty
Cat.No. 1387 - Ac-RYYRWK-NH2 | Ac-Arg-Tyr-Tyr-Arg-Trp-Lys-NH2 | CAS No. 200959-47-3
Description: Potent, selective NOP partial agonist peptide
Datasheet
Citations
Literature

Biological Activity

Potent, selective partial agonist peptide for the NOP receptor (Ki = 0.71 nM). Selective over μ, δ and κ opioid receptors (IC50 > 4000 nM). Increases food intake in vivo.

Technical Data

M. Wt 1012.17
Formula C49H69N15O9
Sequence RYYRWK

(Modifications: Arg-1 = C-terminal Ac, Lys-6 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 200959-47-3
PubChem ID 9811889
InChI Key YROQVQIJRORFAZ-SKGSPYGFSA-N
Smiles CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1012.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.99 mL 4.94 mL 9.88 mL
5 mM 0.2 mL 0.99 mL 1.98 mL
10 mM 0.1 mL 0.49 mL 0.99 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Dooley et al (1997) Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J.Pharmacol.Exp.Ther. 283 735 PMID: 9353393

Ho et al (2000) Characterization of the ORL1 receptor on adrenergic nerve in the rat anococcygeus. Br.J.Pharmacol. 131 349 PMID: 10991930


If you know of a relevant reference for Ac-RYYRWK-NH2, please let us know.

View Related Products by Target

View Related Products by Product Action

View all NOP Receptor Agonists

Keywords: Ac-RYYRWK-NH2, supplier, Potent, selective, NOP, partial, agonists, peptide, Nociceptin, Receptors, ORL1, OP4, Opioid, NOP, Receptors, NOP, Receptors, Tocris Bioscience

Citations for Ac-RYYRWK-NH2

Citations are publications that use Tocris products.

Currently there are no citations for Ac-RYYRWK-NH2. Do you know of a great paper that uses Ac-RYYRWK-NH2 from Tocris? If so please let us know.

Ac-RYYRWK-NH2 Reviews

Average Rating:

(Based on 0 Reviews)


1 Star
0%
2 Star
0%
3 Star
0%
4 Star
0%
5 Star
0%

Have you used Ac-RYYRWK-NH2?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.


Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.