AC 261066

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Cat.No. 4046 - AC 261066 | C17H20FNO4S | CAS No. 870773-76-5
Description: RARβ2 agonist
Chemical Name: 4-[4-(2-Butoxyethoxy-)-5-methyl-2-thiazolyl]-2-fluorobenzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Potent RARβ2 agonist (pEC50 = 8.1). Selective over RARβ1, RARα and RARγ (pEC50 values are 6.4, 6.2 and 6.3 respectively). More potent and orally available than AC 55649 (Cat. No. 2436).

Compound Libraries

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Technical Data

M. Wt 353.41
Formula C17H20FNO4S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 870773-76-5
PubChem ID 11530459
InChI Key HSAOETBFVAWNRP-UHFFFAOYSA-N
Smiles CC1=C(OCCOCCCC)N=C(C2=CC=C(C(O)=O)C(F)=C2)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.34 100
ethanol 35.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 353.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.15 mL 28.3 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.41 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References

References are publications that support the biological activity of the product.

Lund et al (2005) Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist. J.Med.Chem. 48 7517 PMID: 16302793

Lund et al (2009) Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor β ligands. J.Med.Chem. 52 1540 PMID: 19239230


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Keywords: AC 261066, AC 261066 supplier, AC261066, RAR, retinoic, acid, receptor, agonists, beta, b, β, agonist, Retinoic, Acid, Receptors, 4046, Tocris Bioscience

Citations for AC 261066

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