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Biological Activity for AC 261066
AC 261066 is a potent RARβ2 agonist (pEC50 = 8.1). Selective over RARβ1, RARα and RARγ (pEC50 values are 6.4, 6.2 and 6.3 respectively). More potent and orally available than AC 55649 (Cat. No. 2436).
Compound Libraries for AC 261066
Technical Data for AC 261066
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AC 261066
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for AC 261066
The following data is based on the product molecular weight 353.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.83 mL||14.15 mL||28.3 mL|
|5 mM||0.57 mL||2.83 mL||5.66 mL|
|10 mM||0.28 mL||1.41 mL||2.83 mL|
|50 mM||0.06 mL||0.28 mL||0.57 mL|
References for AC 261066
References are publications that support the biological activity of the product.
Lund et al (2005) Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist. J.Med.Chem. 48 7517 PMID: 16302793
Lund et al (2009) Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor β ligands. J.Med.Chem. 52 1540 PMID: 19239230
If you know of a relevant reference for AC 261066, please let us know.
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Keywords: AC 261066, AC 261066 supplier, AC261066, RAR, retinoic, acid, receptor, agonists, beta, b, β, agonist, Retinoic, Acid, Receptors, 4046, Tocris Bioscience
Citations for AC 261066
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Literature in this Area
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