AC 55649

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Cat.No. 2436 - AC 55649 | C21H26O2 | CAS No. 59662-49-6
Description: Selective RARβ2 agonist
Chemical Name: 4'-Octyl-[1,1'-biphenyl]-4-carboxylic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews
Literature

Biological Activity

Potent, isoform-selective RARβ2 receptor agonist (pEC50 values are 6.9, 5.7 and 5.6 at RARβ2, RARβ1 and RARα respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.

Compound Libraries

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Technical Data

M. Wt 310.44
Formula C21H26O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 59662-49-6
PubChem ID 1714884
InChI Key HXBKPYIEQLLNBK-UHFFFAOYSA-N
Smiles CCCCCCCCC1=CC=C(C=C1)C1=CC=C(C=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.04 100
ethanol 7.76 25

Preparing Stock Solutions

The following data is based on the product molecular weight 310.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.22 mL 16.11 mL 32.21 mL
5 mM 0.64 mL 3.22 mL 6.44 mL
10 mM 0.32 mL 1.61 mL 3.22 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Lund et al (2005) Discovery of a potent, orally available, and isoform-selective retinoic acid β2 receptor agonist. J.Med.Chem. 48 7517 PMID: 16302793

Lund et al (2009) Design, synthesis, and structure-activity analysis of isoform selective retinoic acid receptor ligands. J.Med.Chem. 52 1540 PMID: 19239230


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Keywords: AC 55649, AC 55649 supplier, Selective, RARβ, RARbeta2, agonists, RAMBA, Retinoic, Acid, Receptors, AC55649, 2436, Tocris Bioscience

5 Citations for AC 55649

Citations are publications that use Tocris products. Selected citations for AC 55649 include:

Shrestha et al (2017) Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells. Nat Commun 8 150 PMID: 28751710

Lee et al (2017) Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations. Cell Stem Cell 21 179 PMID: 28777944

Kelley (2017) Retinoic acid receptor gamma impacts cellular adhesion, Alpha5 Beta1 integrin expression and proliferation in K562 cells. PLoS One 12 e0178116 PMID: 28552962

Kang et al (2011) Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells. Front Behav Neurosci 4 66 PMID: 20664575

Tay et al (2010) A comparison of the roles of peroxisome proliferator-activated receptor and retinoic acid receptor on CYP26 regulation. Mol Pharmacol 77 218 PMID: 19884280


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Literature in this Area

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Retinoid Receptors

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.