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AC 253

Cat. No. 6550 Submit a Review Datasheet / COA / SDS

Discontinued Product

AC 253 (Cat. No. 6550) has been withdrawn from sale for commercial reasons.
Description: Amylin (AMY3) antagonist
Datasheet
Citations
Reviews
Literature (3)
Biological Activity Technical Data Datasheets References

Biological Activity for AC 253

AC 253 is an amylin (AMY3) receptor antagonist. Inhibits andrenomedulin-stimulated cAMP production in vitro. Protects against oligomeric Aβ-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. Blocks electrophysiological effects of Aβ in vitro. Cyclic AC 253 (Cat.No. 6550) also available.

Technical Data for AC 253

M. Wt 2847.11
Formula C122H196N40O39
Sequence LGRLSQELHRLQTYPRTNTGSNTY

(Modifications: Leu-1 = N-terminal Ac, Tyr-24 = C-terminal amide)
Storage Store at -20°C
CAS Number 151804-79-4
PubChem ID 134160251
InChI Key QOVDFCPGVUGNIP-MLZIZKOLSA-N
Smiles CC(C)C[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for AC 253

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