AC 253

Pricing Availability Delivery Time Qty
Cat.No. 6550 - AC 253 | Ac-Leu-Gly-Arg-Leu-Ser-Gln-Glu-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2 | CAS No. 151804-79-4
Description: Amylin (AMY3) receptor antagonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Amylin (AMY3) receptor antagonist. Inhibits andrenomedulin-stimulated cAMP production in vitro. Protects against oligomeric Aβ-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. Blocks electrophysiological effects of Aβ in vitro. Cyclic AC 253 (Cat.No. 6550) also available.

Technical Data

M. Wt 2847.11
Formula C122H196N40O39
Sequence LGRLSQELHRLQTYPRTNTGSNTY

(Modifications: Leu-1 = N-terminal Ac, Tyr-24 = C-terminal amide)

Storage Store at -20°C
CAS Number 151804-79-4
PubChem ID 16133792
InChI Key ZLFXHYNEZYAYPG-AABHONRUSA-N
Smiles CC(C)C[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2847.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.35 mL 1.76 mL 3.51 mL
5 mM 0.07 mL 0.35 mL 0.7 mL
10 mM 0.04 mL 0.18 mL 0.35 mL
50 mM 0.01 mL 0.04 mL 0.07 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Coppock et al (1999) Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity. Biochem.J. 338 15 PMID: 9931292

Jhamandas et al (2011) Actions of β-amyloid protein on human neurons are expressed through the amylin receptor. Am.J.Pathol. 178 140 PMID: 21224052

Fu et al (2012) Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways. J,Biol.Chem. 287 18820 PMID: 22500019


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