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Amylin (AMY3) antagonist (IC50 = 0.3 μM). Protects neuronal cells from Aβ(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Aβ plaque number and total area in a mouse Alzheimer's disease model.
Sold under license from the University of Alberta, US patent 2,967,616, Canadian patent 15/705,789.
(Modifications: Cys-26 = C-terminal amide, Disulfide bridge between 1 - 26)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Soudy et al (2016) Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease. Alzheimers Dement. (N Y) 3 44 PMID: 29067318
Mietlicki-Baase (2018) Amylin in Alzheimer's disease: Pathological peptide or potential treatment? Neuropharmacology 136 287 PMID: 29233636
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Keywords: cAC 253, cAC 253 supplier, cAC253, amylin, antagonists, antagonism, brain, penetrant, AMY3, amyloid, beta, β, Abeta, Calcitonin, and, Related, Receptors, Amyloid, Beta, Peptides, 6549, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.