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Submit ReviewAA 29504
Description: Positive allosteric modulator of GABAA receptors
Chemical Name: N1-Ethoxycarbonyl-N4-[(2,4,6-trimethylpheny)lmethyl]-1,2,4-triaminobenzene
Purity: ≥98% (HPLC)
Biological Activity
Positive allosteric modulator of GABAA receptors. Modulates both α4β3δ-containing extrasynaptic receptors and α1β3γ2S-containing receptors in Xenopus oocytes, displaying a stronger modulatory effect at the former. Reduces motor coordination and exhibits anxiolytic effects in vivo.
Compound Libraries
AA 29504 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 327.42 |
| Formula | C19H25N3O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 945828-50-2 |
| PubChem ID | 23188887 |
| InChI Key | SCOOTUMXCXKEAD-UHFFFAOYSA-N |
| Smiles | NC1=C(NC(OCC)=O)C=CC(NCC2=C(C)C=C(C)C=C2C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.74 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 327.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.05 mL | 15.27 mL | 30.54 mL |
| 5 mM | 0.61 mL | 3.05 mL | 6.11 mL |
| 10 mM | 0.31 mL | 1.53 mL | 3.05 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.61 mL |
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References
References are publications that support the biological activity of the product.
Hoestgaard-Jensen et al (2010) Pharmacological characterization of a novel positive modulator at α4β3δ-containing extrasynaptic GABAA receptors. Neuropharmacology 58 702 PMID: 20060846
Olander et al (2018) Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors. Biochem. Pharmacol. PMID: 29454619
If you know of a relevant reference for AA 29504, please let us know.
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Keywords: AA 29504, AA 29504 supplier, GABAA, positive, allosteric, modulators, pams, alpha4beta3delta, a4b3d, α4β3γ, anxiolytic, gamma-aminobutyric, acid, AA29504, Receptors, 3972, Tocris Bioscience
1 Citation for AA 29504
Citations are publications that use Tocris products. Selected citations for AA 29504 include:
Olander et al (2018) Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors. Biochem.Pharmacol. 150 305 PMID: 29454619
Do you know of a great paper that uses AA 29504 from Tocris? Please let us know.
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