AA 29504

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Cat.No. 3972 - AA 29504 | C19H25N3O2 | CAS No. 945828-50-2
Description: Positive allosteric modulator of GABAA receptors
Chemical Name: N1-Ethoxycarbonyl-N4-[(2,4,6-trimethylpheny)lmethyl]-1,2,4-triaminobenzene
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Positive allosteric modulator of GABAA receptors. Modulates both α4β3δ-containing extrasynaptic receptors and α1β3γ2S-containing receptors in Xenopus oocytes, displaying a stronger modulatory effect at the former. Reduces motor coordination and exhibits anxiolytic effects in vivo.

Compound Libraries

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Technical Data

M. Wt 327.42
Formula C19H25N3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 945828-50-2
PubChem ID 23188887
InChI Key SCOOTUMXCXKEAD-UHFFFAOYSA-N
Smiles NC1=C(NC(OCC)=O)C=CC(NCC2=C(C)C=C(C)C=C2C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 327.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.05 mL 15.27 mL 30.54 mL
5 mM 0.61 mL 3.05 mL 6.11 mL
10 mM 0.31 mL 1.53 mL 3.05 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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References

References are publications that support the biological activity of the product.

Hoestgaard-Jensen et al (2010) Pharmacological characterization of a novel positive modulator at α4β3δ-containing extrasynaptic GABAA receptors. Neuropharmacology 58 702 PMID: 20060846

Olander et al (2018) Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors. Biochem. Pharmacol. PMID: 29454619


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Keywords: AA 29504, AA 29504 supplier, GABAA, positive, allosteric, modulators, pams, alpha4beta3delta, a4b3d, α4β3γ, anxiolytic, gamma-aminobutyric, acid, AA29504, Receptors, 3972, Tocris Bioscience

1 Citation for AA 29504

Citations are publications that use Tocris products. Selected citations for AA 29504 include:

Olander et al (2018) Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors. Biochem.Pharmacol. 150 305 PMID: 29454619


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Literature in this Area

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*Please note that Tocris will only send literature to established scientific business / institute addresses.


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