A66
Biological Activity
Potent and selective PI 3-kinase p110α inhibitor (IC50 = 32 nM). Exhibits >100-fold selectivity for p110α over other PI 3-kinase isoforms. Inhibits Akt signaling and tumor growth in SK-OV-3 xenografts in mice.
Compound Libraries
A66 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 393.53 |
| Formula | C17H23N5O2S2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1166227-08-2 |
| PubChem ID | 42636535 |
| InChI Key | HBPXWEPKNBHKAX-NSHDSACASA-N |
| Smiles | CC(C)(C)C1=NC(C2=C(C)N=C(NC(N3[C@H](C(N)=O)CCC3)=O)S2)=CS1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.35 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 393.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.54 mL | 12.71 mL | 25.41 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.08 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.54 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Jamieson et al (2011) A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem. J. 438 53 PMID: 21668414
If you know of a relevant reference for A66, please let us know.
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Keywords: A66, supplier, PI, 3-kinase, PI3K, phosphoinositide, 3-kinase, inhibitors, potent, selective, inhibits, p110a, alpha, α, PI, 3-Kinase, PI, 3-Kinase, Tocris Bioscience
Citations for A66
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