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A66

Cat. No. 5595 Submit a Review Datasheet / COA / SDS
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Cat.No. 5595 - A66 | C17H23N5O2S2 | CAS No. 1166227-08-2
Description: Potent and selective PI 3-kinase p110α inhibitor
Chemical Name: (2S)-N1-[2-(1,1-Dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective PI 3-kinase p110α inhibitor (IC50 = 32 nM). Exhibits >100-fold selectivity for p110α over other PI 3-kinase isoforms. Inhibits Akt signaling and tumor growth in SK-OV-3 xenografts in mice.

Compound Libraries

A66 is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 393.53
Formula C17H23N5O2S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1166227-08-2
PubChem ID 42636535
InChI Key HBPXWEPKNBHKAX-NSHDSACASA-N
Smiles CC(C)(C)C1=NC(C2=C(C)N=C(NC(N3[C@H](C(N)=O)CCC3)=O)S2)=CS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.35 100

Preparing Stock Solutions

The following data is based on the product molecular weight 393.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.71 mL 25.41 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References

References are publications that support the biological activity of the product.

Jamieson et al (2011) A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem. J. 438 53 PMID: 21668414

If you know of a relevant reference for A66, please let us know.

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Keywords: A66, A66 supplier, PI, 3-kinase, PI3K, phosphoinositide, inhibitors, potent, selective, inhibits, p110a, alpha, α, 3-Kinase, 5595, Tocris Bioscience

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