A66

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Description: Potent and selective PI 3-kinase p110α inhibitor
Chemical Name: (2S)-N1-[2-(1,1-Dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews

Biological Activity for A66

A66 is a potent and selective PI 3-kinase p110α inhibitor (IC50 = 32 nM). Exhibits >100-fold selectivity for p110α over other PI 3-kinase isoforms. Inhibits Akt signaling and tumor growth in SK-OV-3 xenografts in mice.

Compound Libraries for A66

A66 is also offered as part of the Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for A66

M. Wt 393.53
Formula C17H23N5O2S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1166227-08-2
PubChem ID 42636535
InChI Key HBPXWEPKNBHKAX-NSHDSACASA-N
Smiles CC(C)(C)C1=NC(C2=C(C)N=C(NC(N3[C@H](C(N)=O)CCC3)=O)S2)=CS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A66

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.35 100

Preparing Stock Solutions for A66

The following data is based on the product molecular weight 393.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.71 mL 25.41 mL
5 mM 0.51 mL 2.54 mL 5.08 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References for A66

References are publications that support the biological activity of the product.

Jamieson et al (2011) A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem. J. 438 53 PMID: 21668414


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Keywords: A66, A66 supplier, PI, 3-kinase, PI3K, phosphoinositide, inhibitors, potent, selective, inhibits, p110a, alpha, α, 3-Kinase, 5595, Tocris Bioscience

3 Citations for A66

Citations are publications that use Tocris products. Selected citations for A66 include:

Eugene et al (2020) Increased mitochondrial and lipid metabolism is a conserved effect of Insulin/PI3K pathway downregulation in adipose tissue. Sci Rep 10 3418 PMID: 32099025

Tania et al (2021) Growth and Viability of Cutaneous Squamous Cell Carcinoma Cell Lines Display Different Sensitivities to Isoform-Specific Phosphoinositide 3-Kinase Inhibitors. Int J Mol Sci 22 PMID: 33808215

Christos et al (2021) Dominant Role of PI3K p110α over p110β in Insulin and β-Adrenergic Receptor Signalling. Int J Mol Sci 22 PMID: 34884613


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