High affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM). Attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 512.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.95 mL||9.75 mL||19.5 mL|
|5 mM||0.39 mL||1.95 mL||3.9 mL|
|10 mM||0.19 mL||0.97 mL||1.95 mL|
|50 mM||0.04 mL||0.19 mL||0.39 mL|
References are publications that support the biological activity of the product.
Cao et al (2014) Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci.Rep. 4 4965 PMID: 24828823
If you know of a relevant reference for A01, please let us know.
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Keywords: A01, A01 supplier, A01, bone, morphogenetic, proteins, high, affinity, smurf1, e3, ubiquitin, ligase, inhibitors, inhibits, smad, osteoblasts, BMP, and, Other, Activin, Receptors, Ubiquitin, E3, Ligases, 5397, Tocris Bioscience
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