A 939572

Pricing Availability   Qty
Description: Potent SCD-1 inhibitor
Chemical Name: 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity for A 939572

A 939572 is a potent stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50 = 0.4 nM). Selective for SCD1 over a range of kinases and hERG channels. Inhibits proliferation of squamous cell carcinoma FaDu cells in vitro. Also induces cell death of undifferentiated human embryonic stem cells (ESCs). Orally bioavailable.

Compound Libraries for A 939572

A 939572 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for A 939572

M. Wt 387.86
Formula C20H22ClN3O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1032229-33-6
PubChem ID 24905400
Smiles O=C(NC3=CC(C(NC)=O)=CC=C3)N1CCC(OC2=C(Cl)C=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A 939572

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 38.79 100

Preparing Stock Solutions for A 939572

The following data is based on the product molecular weight 387.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.58 mL 12.89 mL 25.78 mL
5 mM 0.52 mL 2.58 mL 5.16 mL
10 mM 0.26 mL 1.29 mL 2.58 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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References for A 939572

References are publications that support the biological activity of the product.

Ben-David et al (2013) Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell 12 167 PMID: 23318055

Xin et al (2008) Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. Bioorg.Med.Chem.Lett. 18 4298 PMID: 18632269

If you know of a relevant reference for A 939572, please let us know.

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1 Citation for A 939572

Citations are publications that use Tocris products. Selected citations for A 939572 include:

Lien et al (2021) Low glycaemic diets alter lipid metabolism to influence tumour growth Nature 599 302 PMID: 34671163

Do you know of a great paper that uses A 939572 from Tocris? Please let us know.

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