A 1120

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Cat.No. 3793 - A 1120 | C20H19F3N2O3 | CAS No. 1152782-19-8
Description: High affinity retinol-binding protein 4 (RBP4) ligand
Chemical Name: 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity retinol-binding protein 4 (RBP4) ligand (Ki = 8.3 nM); non-retinoid. Selective against a range of different cellular targets. As efficacious as fenretinide (Cat. No. 1396) in the reduction of serum RBP4 and retinol. Displaces transthyretin (TTR) from RBP4-TTR complexes.

Compound Libraries

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Technical Data

M. Wt 392.37
Formula C20H19F3N2O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1152782-19-8
PubChem ID 25138295
InChI Key MEAQCLPMSVEOQF-UHFFFAOYSA-N
Smiles O=C(NC3=C(C(O)=O)C=CC=C3)N1CCC(C2=C(C(F)(F)F)C=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.24 100
ethanol 9.81 25

Preparing Stock Solutions

The following data is based on the product molecular weight 392.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.49 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Manolescu et al (2009) All-trans retinoic acid lowers serum retinol-binding protein 4 concentrations and increases insulin sensitivity in diabetic mice. J.Nutr. 140 311 PMID: 20032483

Motani et al (2009) Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J.Biol.Chem. 284 7673 PMID: 19147488


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Keywords: A1120 non-retinoid retinol-binding proteins 4 RBP4 ligands adipokines Miscellaneous Compounds

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