8-CPT-2Me-cAMP, sodium salt

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Cat.No. 1645 - 8-CPT-2Me-cAMP, sodium salt | C17H16ClN5O6PS.Na | CAS No. 634207-53-7
Description: Selective Epac activator
Chemical Name: 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate sodium salt
Purity: ≥99% (HPLC)
Citations (8)

Biological Activity

Selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 > 10 μM). Stimulates Epac-mediated Ca2+-mediated Ca2+ release in pancreatic β-cells in vitro. Cell permeable analog (Cat. No. 4853) also available.

Licensing Information

Sold with the permission of BioLog Life Science Institute

Technical Data

M. Wt 507.82
Formula C17H16ClN5O6PS.Na
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 634207-53-7
PubChem ID 16759604
Smiles [Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](OC)[C@@H](O2)N1C(SC2=CC=C(Cl)C=C2)=NC2=C1N=CN=C2N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 50.78 100

Preparing Stock Solutions

The following data is based on the product molecular weight 507.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.85 mL 19.69 mL
5 mM 0.39 mL 1.97 mL 3.94 mL
10 mM 0.2 mL 0.98 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Enserink et al (2002) A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat.Cell.Biol. 4 901 PMID: 12402047

Kang et al (2003) Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic βcells. J.Biol.Chem. 278 8279 PMID: 12496249

Kawasaki et al (1998) A family of cAMP-binding proteins that directly activate Rap1. Science 282 2275 PMID: 9856955

If you know of a relevant reference for 8-CPT-2Me-cAMP, sodium salt, please let us know.

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Keywords: 8-CPT-2Me-cAMP, sodium salt, supplier, Selective, Epacs, epac, activators, G, Proteins, Small, Rap1, Rap2, GTPase, GTPase, G, Proteins, (Small), GTPase, Tocris Bioscience

8 Citations for 8-CPT-2Me-cAMP, sodium salt

Citations are publications that use Tocris products. Selected citations for 8-CPT-2Me-cAMP, sodium salt include:

Garcia-Murillas et al (2014) An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer. Oncogene 33 2478 PMID: 23752180

Guichard et al (2013) Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. Cell Host Microbe 14 294 PMID: 24034615

Hutchison and White (2015) Prostacyclin regulates bone growth via the Epac/Rap1 pathway. PLoS One 156 499 PMID: 25406016

Mohan et al (2015) Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity. Endocrinology 46 53 PMID: 25451967

Hu et al (2012) Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity. Proc Natl Acad Sci U S A 109 17681 PMID: 23045693

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID: 21143600

Soltoff and Hedden (2010) Isoproterenol and cAMP block ERK phosphorylation and enhance [Ca2+]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells. J Biol Chem 285 13337 PMID: 20207737

Jeong et al (2007) IQGAP1 binds Rap1 and modulates its activity. J Biol Chem 282 20752 PMID: 17517894

Do you know of a great paper that uses 8-CPT-2Me-cAMP, sodium salt from Tocris? If so please let us know.

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