8-CPT-2Me-cAMP, sodium salt

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Description: Selective Epac activator
Chemical Name: 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate sodium salt
Purity: ≥99% (HPLC)
Citations (11)

Biological Activity for 8-CPT-2Me-cAMP, sodium salt

8-CPT-2Me-cAMP, sodium salt is a selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 > 10 μM). Stimulates Epac-mediated Ca2+-mediated Ca2+ release in pancreatic β-cells in vitro. Cell permeable analog (Cat. No. 4853) also available.

Licensing Information

Sold with the permission of BioLog Life Science Institute

Technical Data for 8-CPT-2Me-cAMP, sodium salt

M. Wt 507.82
Formula C17H16ClN5O6PS.Na
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 634207-53-7
PubChem ID 16759604
Smiles [Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](OC)[C@@H](O2)N1C(SC2=CC=C(Cl)C=C2)=NC2=C1N=CN=C2N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 8-CPT-2Me-cAMP, sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
water 50.78 100

Preparing Stock Solutions for 8-CPT-2Me-cAMP, sodium salt

The following data is based on the product molecular weight 507.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.85 mL 19.69 mL
5 mM 0.39 mL 1.97 mL 3.94 mL
10 mM 0.2 mL 0.98 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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Product Datasheets for 8-CPT-2Me-cAMP, sodium salt

Certificate of Analysis / Product Datasheet
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References for 8-CPT-2Me-cAMP, sodium salt

References are publications that support the biological activity of the product.

Enserink et al (2002) A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat.Cell.Biol. 4 901 PMID: 12402047

Kang et al (2003) Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic βcells. J.Biol.Chem. 278 8279 PMID: 12496249

Kawasaki et al (1998) A family of cAMP-binding proteins that directly activate Rap1. Science 282 2275 PMID: 9856955

If you know of a relevant reference for 8-CPT-2Me-cAMP, sodium salt, please let us know.

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Keywords: 8-CPT-2Me-cAMP, sodium salt, 8-CPT-2Me-cAMP, sodium salt supplier, Selective, Epacs, epac, activators, G, Proteins, Small, Rap1, Rap2, GTPase, EPAC, 1645, Tocris Bioscience

11 Citations for 8-CPT-2Me-cAMP, sodium salt

Citations are publications that use Tocris products. Selected citations for 8-CPT-2Me-cAMP, sodium salt include:

Hutchison and White (2015) Prostacyclin regulates bone growth via the Epac/Rap1 pathway. PLoS One 156 499 PMID: 25406016

Guichard et al (2013) Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. Cell Host Microbe 14 294 PMID: 24034615

Scheibner et al (2009) The adenosine a2a receptor inhibits matrix-induced inflammation in a novel fashion. Am J Respir Cell Mol Biol 40 251 PMID: 18703794

Hu et al (2012) Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity. Proc Natl Acad Sci U S A 109 17681 PMID: 23045693

Do you know of a great paper that uses 8-CPT-2Me-cAMP, sodium salt from Tocris? Please let us know.

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