8-CPT-2Me-cAMP, sodium salt

Pricing Availability   Qty
Cat.No. 1645 - 8-CPT-2Me-cAMP, sodium salt | C17H16ClN5O6PS.Na | CAS No. 634207-53-7
Description: Selective Epac activator
Chemical Name: 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate sodium salt
Purity: ≥99% (HPLC)
Citations (11)

Biological Activity

Selective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 > 10 μM). Stimulates Epac-mediated Ca2+-mediated Ca2+ release in pancreatic β-cells in vitro. Cell permeable analog (Cat. No. 4853) also available.

Licensing Information

Sold with the permission of BioLog Life Science Institute

Technical Data

M. Wt 507.82
Formula C17H16ClN5O6PS.Na
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 634207-53-7
PubChem ID 16759604
Smiles [Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](OC)[C@@H](O2)N1C(SC2=CC=C(Cl)C=C2)=NC2=C1N=CN=C2N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 50.78 100

Preparing Stock Solutions

The following data is based on the product molecular weight 507.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.85 mL 19.69 mL
5 mM 0.39 mL 1.97 mL 3.94 mL
10 mM 0.2 mL 0.98 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:


References are publications that support the biological activity of the product.

Enserink et al (2002) A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat.Cell.Biol. 4 901 PMID: 12402047

Kang et al (2003) Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic βcells. J.Biol.Chem. 278 8279 PMID: 12496249

Kawasaki et al (1998) A family of cAMP-binding proteins that directly activate Rap1. Science 282 2275 PMID: 9856955

If you know of a relevant reference for 8-CPT-2Me-cAMP, sodium salt, please let us know.

View Related Products by Target

View Related Products by Product Action

View all EPAC Activators

Keywords: 8-CPT-2Me-cAMP, sodium salt, 8-CPT-2Me-cAMP, sodium salt supplier, Selective, Epacs, epac, activators, G, Proteins, Small, Rap1, Rap2, GTPase, EPAC, 1645, Tocris Bioscience

11 Citations for 8-CPT-2Me-cAMP, sodium salt

Citations are publications that use Tocris products. Selected citations for 8-CPT-2Me-cAMP, sodium salt include:

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984 PMID: 21143600

Garcia-Murillas et al (2014) An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer. Oncogene 33 2478 PMID: 23752180

Jeong et al (2007) IQGAP1 binds Rap1 and modulates its activity. J Biol Chem 282 20752 PMID: 17517894

Hu et al (2012) Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity. Proc Natl Acad Sci U S A 109 17681 PMID: 23045693

Soltoff and Hedden (2010) Isoproterenol and cAMP block ERK phosphorylation and enhance [Ca2+]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells. J Biol Chem 285 13337 PMID: 20207737

Ng (2018) Inhibition of cytokine-mediated JNK signalling by purinergic P2Y11 receptors, a novel protective mechanism in endothelial cells. Cell Signal 51 59 PMID: 30076967

Himer et al (2010) Adenosine A2A receptor activation protects CD4+ T lymphocytes against activation-induced cell death. FASEB J 24 2631 PMID: 20371613

Guichard et al (2013) Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. Cell Host Microbe 14 294 PMID: 24034615

Scheibner et al (2009) The adenosine a2a receptor inhibits matrix-induced inflammation in a novel fashion. Am J Respir Cell Mol Biol 40 251 PMID: 18703794

Hutchison and White (2015) Prostacyclin regulates bone growth via the Epac/Rap1 pathway. PLoS One 156 499 PMID: 25406016

Mohan et al (2015) Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity. Endocrinology 46 53 PMID: 25451967

Do you know of a great paper that uses 8-CPT-2Me-cAMP, sodium salt from Tocris? Please let us know.

Reviews for 8-CPT-2Me-cAMP, sodium salt

There are currently no reviews for this product. Be the first to review 8-CPT-2Me-cAMP, sodium salt and earn rewards!

Have you used 8-CPT-2Me-cAMP, sodium salt?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

New Product Guide

New Product Guide (Fall/Winter 2018/2019)

Our new product guide highlights over 190 new products added to the Tocris Bioscience range during the second half of 2018.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells