This ligand has uniquely high affinity and selectivity for the D3 receptor. 8-Hydroxy-PIPAT maleate (Cat. No. 0797) also available.
Sold with the permission of the University of Pennsylvania
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 487.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.05 mL||10.26 mL||20.52 mL|
|5 mM||0.41 mL||2.05 mL||4.1 mL|
|10 mM||0.21 mL||1.03 mL||2.05 mL|
|50 mM||0.04 mL||0.21 mL||0.41 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Chumpradit et al (1993) Synthesis and optical resolution of (R)- and (S)-trans-7-hydroxy-2-[N-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin: a new D3 dopamine receptor ligand. J.Med.Chem. 36 4308 PMID: 8277513
Foulon et al (1993) Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-amino]tetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand. J.Med.Chem. 36 1499 PMID: 8098771
Kung et al (1993) In vitro binding of a novel dopamine D3 receptor ligand: [125I]-trans-7-OH-PIPAT. Eur.J.Pharmacol. 235 165 PMID: 8519278
If you know of a relevant reference for 7-Hydroxy-PIPAT maleate, please let us know.
View Related Products by Product Action
Keywords: D3 agonists Dopamine Receptors dopaminergic 7-OH-PIPAT D3 Receptors
Citations for 7-Hydroxy-PIPAT maleate
Citations are publications that use Tocris products.
Currently there are no citations for 7-Hydroxy-PIPAT maleate. Do you know of a great paper that uses 7-Hydroxy-PIPAT maleate from Tocris? If so please let us know.
Literature in this Area
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.