7-Hydroxy-PIPAT maleate

Discontinued Product

7-Hydroxy-PIPAT maleate (Cat. No. 0719) has been withdrawn from sale for commercial reasons.
Description: D3 agonist (D3 > D2)
Alternative Names: 7-OH-PIPAT
Chemical Name: (RS)-trans-7-Hydroxy-2-[N-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin maleate
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for 7-Hydroxy-PIPAT maleate

This ligand has uniquely high affinity and selectivity for the D3 receptor. 8-Hydroxy-PIPAT maleate (Cat. No. 0797) also available.

Licensing Information

Sold with the permission of the University of Pennsylvania

Technical Data for 7-Hydroxy-PIPAT maleate

M. Wt 487.33
Formula C16H22INO.C4H4O4
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 200722-46-9
PubChem ID 24978534
Smiles OC(=O)\C=C/C(O)=O.CCCN(C\C=C\I)C1CCC2=CC=C(O)C=C2C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for 7-Hydroxy-PIPAT maleate

References for 7-Hydroxy-PIPAT maleate

References are publications that support the biological activity of the product.

Chumpradit et al (1993) Synthesis and optical resolution of (R)- and (S)-trans-7-hydroxy-2-[N-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin: a new D3 DA receptor ligand. J.Med.Chem. 36 4308 PMID: 8277513

Foulon et al (1993) Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-amino]tetralin (trans-7-OH-PIPAT): a new D3 DA receptor ligand. J.Med.Chem. 36 1499 PMID: 8098771

Kung et al (1993) In vitro binding of a novel DA D3 receptor ligand: [125I]-trans-7-OH-PIPAT. Eur.J.Pharmacol. 235 165 PMID: 8519278

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Keywords: 7-Hydroxy-PIPAT maleate, 7-Hydroxy-PIPAT maleate supplier, D3, agonists, Dopamine, Receptors, dopaminergic, 7-OH-PIPAT, 0719, Tocris Bioscience

Citations for 7-Hydroxy-PIPAT maleate

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Currently there are no citations for 7-Hydroxy-PIPAT maleate.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.